Analysis of the interactions of collectins with immunoglobuins and the regulation immunoglobulin functions
| Project/Area Number |
20570136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
SHIMIZU Takeyuki Sapporo Medical University, 教育研究部・医療学系, 准教授 (10339137)
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| Co-Investigator(Kenkyū-buntansha) |
KUROKI Yoshio 札幌医科大学, 医学部, 教授 (70161784)
NISHITANI Chiaki 札幌医科大学, 医学部, 助教 (30381255)
ARIKI Shigeru 札幌医科大学, 医学部, 助教 (80464478)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 免疫学 / 蛋白質 / 生体分子 / コレクチン / 免疫グロブリン |
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| Research Abstract |
We found that MBL and SP-D bound to IgM through CRD. The interactions between MBL and IgM in immune complexes depended on the affinity and antigen-density. These results suggest that antigen-bound IgM can take different conformations, which are distinguished by MBL. We also found that MBL can modulate classical pathway of complement cascade.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophlla and suppress its intracellular growth2010
Author(s)
Kaku Sawada, Shigeru Ariki, Takashi Kojima, Atsushi Saito, Masami Yamazoe, Chiaki Nishitani, Takeyuki Shimizu, Motoko Takahashi, Hiroaki Mitsuzawa, Shin-ichi Yokota, Norimasa Sawada, Nobuhiro Fujii, Hiroki Takahashi, Yoshio Kuroki.
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Journal Title
J.Biol.Chem. vol.285
Pages: 8434-8443
Related Report
Peer Reviewed
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[Journal Article] Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors2008
Author(s)
Masami Yamazoe, Chiaki Nishitani, Motoko Takahashi, Tsuyoshi Katoh, Shigeru Ariki, Takeyuki Shimizu, Hiroaki Mitsuzawa, Kaku Sawada, Dennis R.Voelker, Hiroki Takahashi, Yoshio Kuroki.
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Journal Title
J.Biol.Chem. vol.283
Pages: 35878-35888
Related Report
Peer Reviewed
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[Journal Article] Pulmonary surfactant protein D binds MD-2 through the carbohydrate recognition domain2008
Author(s)
Xiaomeng Nie, Chiaki Nishitani, Masami Yamazoe, Shigeru Ariki, Motoko Takahashi, Takeyuki Shimizu, Hiroaki Mitsuzawa, Kaku Sawada, Kelly Smith, Erika Crouch, Hisato Nagae, Hiroki Takahashi, Yoshio Kuroki.
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Journal Title
Biochemistry vol.47
Pages: 12878-12885
Related Report
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