Studies on orphan G protein-coupled receptors which are related to body size : ligand search and their functions
Project/Area Number |
20570140
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Functional biochemistry
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Research Institution | Tohoku Pharmaceutical University |
Principal Investigator |
MITOMA Junya Tohoku Pharmaceutical University, 薬学部, 講師 (10281627)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Keywords | シグナル伝達 / 糖 / 糖尿病 / GPCR / リガンド / Gタンパク共役型受容体 / オーファン受容体 / cAMP / カルシウムシグナリング / ノックアウトマウス / インスリン |
Research Abstract |
We found that the mice deficient in G protein-coupled receptor Rigp2 (Rigp2-/-) are significantly smaller than wild-type mice. Because the number of Rigp2-/- mice born from heterozygote mating is much smaller than that of Rigp2+/- and +/+ mice, there may be some defect during development. We also found that the only one of Asp residues of this protein has N-linked glycans. We could not identify a ligand for this GPCR.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] The N-glycolyl form of mouse sialyl Lewis X is recognized by selectins but not by HECA-452 and FH6 antibodies that were raised against human cells.2009
Author(s)
Mitoma, J., Miyazaki, T., Sutton-Smith, M., Suzuki, M., Saito, H., Yeh, J. C., Kawano, T., Hindsgaul, O., Seeberger, P.H., Panico, M., Haslam, S.M., Morris, H.R., Cummings, R.D., Dell, A., Fukuda, M.
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Journal Title
Glycoconj.J. 26(5)
Pages: 511-511
Related Report
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[Journal Article] The N-glycolyl form of mouse sialyl Lewis X is recognized by selectins but not by HECA-452 and FH6 antibodies that were raised against human cells2009
Author(s)
Mitoma J, Miyazaki T, Sutton-Smith M, Suzuki M, Saito H, Yeh JC, Kawano T, Hindsgaul O, Seeberger PH, Panico M, Haslam SM, Morris HR, Cummings RD, Dell A, Fukuda Ma
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Journal Title
Glycoconjugate Journal 26
Pages: 511-523
Related Report
Peer Reviewed
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