The Physiological function of V-ATPase involved in membrane traffick
| Project/Area Number |
20570142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
WADA Ge-Hong Doshisha Women's College of Liberal Arts, 薬学部, 教授 (00314427)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 膜輸送と輸送タンパク質 / プロトンポンプ / V-ATPase / プロレニン受容体 / ノックアウトマウス / 骨代謝 / 膜輸送 / 酸性化 / プロトン動態 / オルガネラ酸性化 / 低分子GTPase / 酸性オルガネラ / pH-senser / プロトンの動態 |
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| Research Abstract |
Acidification inside membrane compartments is a common feature of all eukaryotic cells. The acidic milieu, generated by the V-ATPase, is involved in many physiological processes including secretion, protein processing, and others. Using subunit-specific knockout mice, we have shown that the function of V-ATPase is involved in insulin secretion, born resorption and macrophage functions. We have also revealed that the (pro)renin receptor functions as an assembly factor of the V-ATPase complex.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] The (pro)renin receptor/ATP6AP2 is essential for vacuolar H^+-ATPase assembly in murine cardiomyocytes.2010
Author(s)
Kinouchi, K., Ichihara, A., Sano M.Sun-Wada, G-H, Wada, Y., kurauchi-Mito, A., Bokuda, K.
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Journal Title
Circ Res.
Volume: 107
Pages: 30-34
Related Report
Peer Reviewed
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[Journal Article] Generation of chicken monoclonal antibodies against the a1, a2, and a3 subunit isoforms of vacuolar-type proton ATPase.
Author(s)
Sun-Wada, G-H, Tabata H., Kuhara, M., Kitahara, I., Takashima, Y., Wada Y.
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Journal Title
Hybridoma
Volume: (In press)
Related Report
Peer Reviewed
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