| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Acidification inside membrane compartments is a common feature of all eukaryotic cells. The acidic milieu, generated by the V-ATPase, is involved in many physiological processes including secretion, protein processing, and others. Using subunit-specific knockout mice, we have shown that the function of V-ATPase is involved in insulin secretion, born resorption and macrophage functions. We have also revealed that the (pro)renin receptor functions as an assembly factor of the V-ATPase complex.
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