| Project/Area Number |
20570144
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
OKAMOTO Koji National Institute for Basic Biology, 大学院・生命機能研究科, 特任准教授 (40455217)
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| Research Collaborator |
OKAMOTO Noriko 大阪大学, 大学院・生命機能研究科, 特任研究員 (90568750)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | ミトコンドリア / オートファジー / 膜輸送 / オルガネラ / ダイナミクス / 品質管理 / 出芽酵母 / 細胞内分解 / 酸化ストレス / タンパク質標的化 |
|---|
| Research Abstract |
Mitochondria serve as "the power plants of the cell", playing essential roles in cellular functions. Recently, it has been proposed that degradation of mitochondria as whole organelles, termed mitophagy, is critical for mitochondrial quality control. However, the molecular mechanisms remain largely unknown. In this study, we utilized budding yeast, and succeeded to establish selective degradation of mitochondria as a phenomenon to be analyzed, and systematically identify mitophagy-related factors.
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