Immunoregulatory cytokine production and suppression of autoimmune diseases by Vα19 NKT cells
| Project/Area Number |
20570146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Mitsubishi Kagaku Institute of Life Sciences |
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Principal Investigator |
SHIMAMURA Michio Mitsubishi Kagaku Institute of Life Sciences, 研究開発部, 専任研究員 (70399682)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 免疫生化学 / NKT細胞 / 自己免疫病 / アレルギー / 免疫制御 / サイトカイン |
|---|
| Research Abstract |
We have shown that Vα19 NKT cells possess potential to differently response to the stimulation to TCR depending on the intensity and the duration of TCR engagement. In fact disease progress in the models for autoimmunity or allergy was suppressed by the introduction of the invariant Vα19-Jα33 TCR transgene. Furthermore, the suppression was enhanced by the administration of Vα19 NKT cell activator α-ManCer4Ph.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Influenza A infection in suckling mice expands a population of NKT cells that protects mice as adults from airway hyperreactivity.2011
Author(s)
Ya-Jen Chang, Hye Young Kim, Lee A. Albacker, Hyun Hee Lee, Nicole Baumgarth, Shizuo Akira, Paul B. Savage, Shin Endo, Takashi Yamamura, Janneke Maaskant, Naoki Kitano, Abel Singh, Apoorva Bhatt, Gurdyal S. Besra, Peter van den Elzen, Ben Appelmelk, Richard W. Franck, Gwangwu Chen, Rosemarie H. DeKruyff, Michio Shimamura, Petr Illarionov, Dale T. Umetsu
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Journal Title
J.Clin.Invest. 121
Pages: 57-69
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[Presentation] Specific activation of murine and human NKT cells with cholesteryl glycosides produced by Helicobacter pylori2009
Author(s)
Michio Shimamura, Petr Illarionov, Shin Endo, Yi-Ying Huang, Abel Singh, Apoorva Bhatt, Gurdayl S. Besra, Janneke Maaskant, Ben J. Appelmelk, Hye Young Kim, Muriel Pichavant, Dale T. Umetsu
Organizer
5^<th> International Symposium on CD1/NKT cells
Place of Presentation
鎌倉
Year and Date
2009-03-24
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