Molecular analysis of chemically modified tau from pathological view points : fibrous aggregation and environmental interactions
| Project/Area Number |
20570149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAMAI Yoshinori 福井大学, 大学院・工学研究科, 准教授 (50324140)
MORII Takashi 京都大学, エネルギー理工学研究所, 教授 (90222348)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | タンパク質 / 核酸の構造 / 動態 / 機能 / 蛋白質 / アルツハイマー病 / アミロイド / タウ蛋白 / リン酸化 |
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| Research Abstract |
In order to elucidate molecualr mechanisms of phosphorylation effects on tau amyloidgenesis, their aggregation properties and amyloid stuctures were analyzed in detail. A varity of methods used for the analaysis such as a precise determination method of critical concentration of amyloidgenesis and a combination of X-ray fiber diffraction and computer simulation methods were established here. The analysis found critical roles of charges on phosphate residues, position of phosphate on the peptides, and specipic intra-and inter-molecular interaction within the aggregate.
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Report
(4 results)
Research Products
(26 results)
