| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
In order to elucidate molecualr mechanisms of phosphorylation effects on tau amyloidgenesis, their aggregation properties and amyloid stuctures were analyzed in detail. A varity of methods used for the analaysis such as a precise determination method of critical concentration of amyloidgenesis and a combination of X-ray fiber diffraction and computer simulation methods were established here. The analysis found critical roles of charges on phosphate residues, position of phosphate on the peptides, and specipic intra-and inter-molecular interaction within the aggregate.
|
