| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
When forces were applied to the filament, it was severed after the application of cofilin with a significantly larger delay in comparison with the control filaments suspended in solution. The binding rate of cofilin to an actin bundle was decreased when the bundle was tensed. These results demonstrate that tension in the actin filament prevents the binding of cofilin, resulting in a decrease in the effective severing activity of cofilin.
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