| Project/Area Number |
20570157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
FURUNO Tadahide Aichi Gakuin University, 薬学部, 准教授 (80254308)
|
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Mamoru 愛知学院大学, 薬学部, 教授 (90090472)
INOH Yoshikazu 愛知学院大学, 薬学部, 講師 (90434547)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経細胞 / マスト細胞 / 接着分子 / 情報伝達 / アレルギー / 画像解析 / カルシウムシグナル / CADM1 / N-カドヘリン / DRG / シナプス / nectin-3 |
|---|
| Research Abstract |
There has been an exponential increase in data illustrating that the nervous and immune systems are not disparate entities. The nerve-mast cell relationship has served as a prototypic association and has provided substantial evidence for bidirectional communication between nerves and immune cells. Mast cells are closely apposed to nerves in a variety of tissues including skin, intestine, and dura mater. Some mast cells actually form membrane-membrane contact with nerve cells. However, the molecules that sustain this association have not been identified. We here found that an adhesion molecule named cell adhesion molecule 1 (CADM1) on mast cells predominantly mediated the attachment to neurites and promoted their functional communication. In addition, among splicing variants of CADM1, the shortest isoform CADM1d showed a unique feature for the contact strength and communication efficiency in nerves and mast cells.
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