Molecular mechanism of Kid-mediated anaphase chromosome compaction

• Project/Area Number: 20570161
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Molecular biology
• Research Institution: The University of Tokyo
• Principal Investigator: OHSUG Miho The University of Tokyo, 医科学研究所, 准教授 (00332586)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 染色体分配 / 核形成 / キネシンファミリー分子 / 細胞生物学 / クロモキネシン / 核膜形成

Research Abstract

The chromokinesin Kid/kinesin-10 is a multifunctional mitotic motor protein. Kid mediates tight clustering of anaphase chromosomes, which is important for the formation of daughter nuclei that enclosed entire set of segregated chromosomes. In this study, we showed that DNA-binding activity is essential and motor and oligomerization activities are important for the Kid-mediated anaphase chromosome compaction.

Research Products

• [Presentation] マウス前核形成開始タイミングの特殊性 (2010)
  • Author(s): 大杉美穂
  • Organizer: 第51回日本哺乳動物卵子学会
  • Place of Presentation: 新潟
  • Year and Date: 2010-05-29
• [Presentation] マウス卵における減数第二分裂後期の染色体分配と前核形成の特性 (2009)
  • Author(s): 大杉美穂
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] マウス卵における減数第二分裂後期の染色体分配と前核形成の特性 (2009)
  • Author(s): 大杉美穂
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] マウス初期胚における染色体分配と核形成の特性 (2009)
  • Author(s): 大杉美穂
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-21
• [Presentation] マウス初期胚における染色体分配と核形成の特性 (2009)
  • Author(s): 大杉美穂
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2009-10-21
• [Presentation] 哺乳動物初期胚分裂期の特性 (2009)
  • Author(s): 大杉美穂
  • Organizer: 第21回高遠シンポジウム
  • Place of Presentation: 高遠さくらホテル
  • Year and Date: 2009-09-27
• [Presentation] 哺乳動物初期胚分裂期の特性 (2009)
  • Author(s): 大杉美穂
  • Organizer: 第21回高遠シンポジウム
  • Place of Presentation: 伊那
  • Year and Date: 2009-08-27
• [Presentation] Kid-Mediated Anaphase Chromosome Compaction Safeguards Mouse Early Embryos Against Multinuclear Formation (2008)
  • Author(s): 大杉美穂
  • Organizer: The 3^<rd> Asian Chromosome Colloquium 2008
  • Place of Presentation: 大阪
  • Year and Date: 2008-12-03
• [Presentation] Kid-Mediated Anaphase Chromosome Compaction Safeguards Mouse Early EMbryos Against Multinuclear Formation (2008)
  • Author(s): Miho Ohpugi
  • Organizer: The 3rd Asian Chromosome Colloquium 2008
  • Place of Presentation: 大阪大学,コンベンションセンター
  • Year and Date: 2008-12-03
• [Presentation] クロモキネシンKidによる核膜形成制御 (2008)
  • Author(s): 大杉美穂
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] クロモキネシンKidによる核膜形成制御 (2008)
  • Author(s): 大杉美穂
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-28
• [Presentation] KID-MEDIATED ANAPHASE CHROMOSOME COMMPACTION ENSURES MOUSE EARLY EMBRYOS AGAINST MULTINUCLEAR FORMATION (2008)
  • Author(s): 大杉美穂
  • Organizer: 第3回遺伝研国際シンポジウム
  • Place of Presentation: 三島
  • Year and Date: 2008-05-26
• [Presentation] KID-MEDIATED ANAPHASE CHROMOSOME COMPACTION ENSURES OUSE EA RLY EMBRYOS AGAINST MULTINUCLEAR FORMATION (2008)
  • Author(s): Miho Ohsugi
  • Organizer: 第3回遺伝研国際シンポジゥム"Chromosome Dynamics"
  • Place of Presentation: 国立遺伝学研究所
  • Year and Date: 2008-05-26
• [Remarks] ホームページ等
  • URL: http://www.ims.u-tokyo.ac.jp/gannsig/member/ohsugi/MphaseGroup/TOP.html