| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
RNA polymerase II (Pol II) copies genetic information from DNA to RNA. The carboxy-terminal domain (CTD) of Pol II is subjected to reversible phosphorylation during transcription cycle and plays an important role in gene expression. Recently, I identified a novel human protein PCIF1 as a phosphorylated CTD-interacting protein. In this study, I investigated PCIF1's function in gene expression. My data suggests that PCIF1 binds Pol II at promoter region during early phase of transcription cycle and modulates phosphorylation level of the CTD.
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