Transcriptional regulation of cytokines produced in febrile-and inflammatory response by heat shock transcription factor
| Project/Area Number |
20570166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Yasuda Women's University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 転写 / ストレス応答 / 遺伝子 / 熱ショック応答 / 炎症反応 / 転写因子 / サイトカイン / 生体防御 / 発熱 |
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| Research Abstract |
Inflammatory cytokines, such as IL-1, IL-6 and TNF-α, are produced in response to bacterial infections and disease and elicit the febrile response. Fever plays beneficial roles in the clinical prognosis of disease. However, the molecular mechanisms underlining the fever-mediated suppression of inflammatory gene expression have not been clarified. In this study, we showed that heat shock suppresses LPS-induced expression of IL-6.The heat activated heat shock transcription factor 1(HSF1) induced the expression of activating transcription factor 3(ATF3), a negative regulator of the IL-6 gene. A comprehensive analysis revealed that the HSF1-ATF3 pathway was required for heat-mediated suppression of inflammatory genes.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Attenuation of progressive hearing loss in a model of age-related hearing loss by a heat shock protein inducer, Geranylgeranylacetone2008
Author(s)
T. Mikuriya, K. Sugahara, K. Sugimoto, M. Fujimoto, T. Takemoto, M. Hashimoto, Y. Hirose, H. Shimogori, N. Hayashida, S. Inouye, A. Nakai, H. Yamashita
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Journal Title
Brain Research
Volume: 1212
Pages: 9-17
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Peer Reviewed
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[Presentation] Mouse HSF3 can protect cells against detrimental stresses2008
Author(s)
M. Fujimoto, T. Katoh, H. Naoki, R. Takii, I. Ohshima, T. Shinkawa, B. B. Oh, S. Inouye, and A. Nakai
Organizer
Jacques Monod Conference ; New ideas for an old family : Heat Shock Factors at crossroads between stress, epigenetics and development
Place of Presentation
Roscoff, France
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