Study on the molecular mechanisms by which general cell polarity-regulating kinase, PAR-1, regulates epithelial polarity
| Project/Area Number |
20570186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Yokohama City University |
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Principal Investigator |
SUZUKI Atsushi Yokohama City University, 医学研究科, 准教授 (00264606)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞極性 / PAR / 上皮細胞 / 微小管 / aPKC |
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| Research Abstract |
Epithelial cells cover the boundary between our body and external environment, and thus develop functional asymmetry (polarity) between the cell membranes facing internal and external environment. It has been demonstrated that abnormal epithelial polarity leads to physiological deficiency. In this study, we have analyzed how the general cell polarity-regulating protein, PAR-1, plays important roles for epithelial polarity, especially by analyzing its binding proteins.
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Report
(4 results)
Research Products
(46 results)
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[Presentation] 細胞極性による Hippo 経路の抑制がマウス着床前胚における位置依存的な細胞分化をつかさどる2010
Author(s)
平手良和, 平原志乃, 井上健一, 中尾和貴, 鈴木厚, 秋本和憲, 大野茂男, 平井孝明, 千田和広, Marikawa Y, Vernadeth A, 佐々木洋
Organizer
第33回日本分子生物学会年会 第83回日本生化学会大会 合同大会(口頭発表)
Place of Presentation
神戸
Related Report
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