The Interactive Mechanisms of neural cell adhesion molecules ; Protocadherin and IgCAM.
Project/Area Number |
20570187
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cell biology
|
Research Institution | Niigata University |
Principal Investigator |
TAKEUCHI Kosei Niigata University, 医歯学系, 准教授 (90206946)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 脳・神経 / 神経回路 / 細胞接着 / 神経細胞接着 / タンパク質発現 / モデル動物 / 神経回路形成 |
Research Abstract |
Immunoglobulin superfamily cell adhesion molecules (IgCAM) and Proto-cadherin family members (Pcdh) play important roles in the neural network formations. These member proteins have the interaction systems of hemophilic binding and heterophilic bindings to not only various cell adhesion proteins but also many extra cellular proteins (ECMs). IgCAMs and Pcdh were regulated by the expression of chondroitin sulfate proteoglycans especially. We generated the knockout mice of the enzymes involved in the synthesizing of chondroitin sulfate. The expression pattern of IgCAMs and Pcdh were perturbed in the developmental stages of brain formation.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Predicted expansion of the claudin multigene family.2011
Author(s)
Mineta K, Yamamoto Y, Yamazaki Y, Tanaka H, Tada Y, Saito K, Tamura A, Igarashi M, Endo T, Takeuchi K, Tsukita S
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Journal Title
FEBS Lett. 585
Pages: 606-612
Related Report
Peer Reviewed
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[Journal Article] Chondroitinsulfate N-acetylgalactosaminyl-transferase-1 is required for normal cartilage development.2010
Author(s)
Takeuchi K., Watanabe Y., Higa-Onaga S., Sato M., Tsujita M., Abe M., Natsume R., Li M., Furuichi T., Saeki M., Izumikawa T., Hasegawa A., Yokoyama M., Ikegawa S., Sakimura K., Amizuka N., Kitagawa H, Igarashi M.
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Journal Title
Biochem. J.Biochem. J. 432
Pages: 47-55
Related Report
Peer Reviewed
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[Journal Article] Identification of functional marker proteins in themammalian growth cone.2009
Author(s)
Nozumi M., Togano T., Takahashi-Niki K., Lu J., Honda A., Taoka M., Shinkawa T., Koga H., Takeuchi K., Isobe T., Igarashi M.
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Journal Title
Proc.Natl.Acad.Sci.USA 106
Pages: 17211-17216
Related Report
Peer Reviewed
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