| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The enhancers of the regulatory genes for the two signaling centers, anterior neural boundary (ANB) and midbrain-hindbrain boundary (MHB), were identified in zebrafish, and their regulation was analyzed by binding assays and reporter assays. In addition, the role of pou2 in MHB formation was examined by using heat-inducible repressive Pou2, showing the stages of pou2 function and the downstream genes. Furthermore, the phenotypes of a novel developmental mutant was analyzed and its causative gene was explored, resulting in identifying a limited number of candidate genes.
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