Regulatory mechanism of the formation of the signaling center for regionalization of the brain primordium in vertebrate embryos.
| Project/Area Number |
20570197
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Saitama University |
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Principal Investigator |
YAMASU Kyo Saitama University, 大学院・理工学研究科, 教授 (60230439)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMURA Akinori 埼玉大学, 理工学研究科, 助教 (10466691)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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|---|
| Keywords | 脳形成 / 脳部域化 / 遺伝子発現調節 / ゼブラフィッシュ / 発生・分化 / 発生遺伝学 / ゼブラフッシュ / 中脳後脳境界 / 前方神経境界 / Fgf8 / Gbx2 / 転写制御 / 脊椎動物 / ゼブラフイッシュ |
|---|
| Research Abstract |
The enhancers of the regulatory genes for the two signaling centers, anterior neural boundary (ANB) and midbrain-hindbrain boundary (MHB), were identified in zebrafish, and their regulation was analyzed by binding assays and reporter assays. In addition, the role of pou2 in MHB formation was examined by using heat-inducible repressive Pou2, showing the stages of pou2 function and the downstream genes. Furthermore, the phenotypes of a novel developmental mutant was analyzed and its causative gene was explored, resulting in identifying a limited number of candidate genes.
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Report
(4 results)
Research Products
(58 results)
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[Book] 生物の事典2010
Author(s)
石原勝敏、末光隆志総編集,弥益恭
Total Pages
542
Publisher
朝倉書店
Related Report
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