Production of Wnt4b by floor plate cells is essential for the segmental patterning of the vertebral column in medaka
Project/Area Number |
20570199
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Developmental biology
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Research Institution | Tokyo Institute of Technology |
Principal Investigator |
INOHAYA Keiji Tokyo Institute of Technology, 大学院・生命理工学研究科, 助教 (70302958)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 器官形成 / メダカ / 骨形成 / 脊椎発生 / Wnt / 発生・分化 |
Research Abstract |
Analysis of a spontaneous medaka mutant, fused centrum ( fsc), which exhibits fused centra and the absence of the intervertebral ligaments, revealed that fsc encodes wnt4b, which was expressed exclusively in the floor plate. In fsc mutants, wnt4b expression was completely lost in the floor plate and that abnormal conversion of the intervertebral ligament cells into osteoblasts appeared to cause a defect of the intervertebral ligaments. These findings provide a novel perspective on the mechanism of vertebrate development.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] The medaka FoxP2, a homologue of human language gene FOXP2, has a diverged structure and function.2008
Author(s)
Itakura T, Chandra A, Yang Z, Xue X, Wang B, Kimura W, Hikosaka K, Inohaya K, Kudo A, Uezato T, Miura N.
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Journal Title
J.Biochem. 143
Pages: 407-416
NAID
Related Report
Peer Reviewed
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