Mechanism of four-chambered heart formation in the vertebrates
| Project/Area Number |
20570200
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
KOSHIBA Kazuko Tokyo Institute of Technology, 分子細胞生物学研究所, 講師 (30467005)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 発生・分化 / 進化 / 形態形成 / 心臓 / 爬虫類 / 発現制御 / 遺伝子 / ゲノム / 発生 |
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| Research Abstract |
In vertebrates the heart morphology is varied from fish to mammals relating their life style. This fact is well known, but the molecular mechanism that provides such differences between four-chambered animals and non-four-chambered animals is unclear. Non-crocodilian reptiles hold a unique place in the evolution of the heart, as their ventricular chambers are apparent intermediates between three-chambered heart and four-chambered heart. We studied Tbx5 expression pattern in the reptiles and found that a steep and correctly positioned Tbx5 gradient is important for ventricular septum formation. This findings generally support the concept that altered expression of developmental regulators is an important aspect of morphological evolution.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Reptilian heart development and the molecular basis of cardiac chamber evolution.2009
Author(s)
Koshiba-Takeuchi K., Mori A.D., Kaynak B.L., Cebra-Thomas J., Sukonnik T., Georges R.O., Latham S., Beck L., Henkelman R.M., Black B.L., Olson E.N., Wade J., Takeuchi J.K., Nemer M., Gilbert S.F., Bruneau B.G.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Reptilian heart development and the molecular basis of cardiac chamber evolution2009
Author(s)
Koshiba-Takeuchi K., Mori AD., Kaynak BL., Cebra-Thomas J., Sukonnik T., Georges RO., Latham S., Beck L., Henkelman RM., Black BL., Olson EN., Wade J., Takeuchi JK., Nemer M., Gilbert SF., Bruneau BG
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Journal Title
Related Report
Peer Reviewed
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