Integrated analysis of the foregut formation and regionalization of the endoderm
Project/Area Number |
20570207
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Developmental biology
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Research Institution | Tokyo Metropolitan University |
Principal Investigator |
FUKUDA Kimiko Tokyo Metropolitan University, 大学院・理工学研究科, 准教授 (40285094)
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Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 器官形成 / 消化管 / 内胚葉 / シグナル分子 / 消化器官 / 境界形成 / 転写因子 / 相互作用 / 領域化 / マイクロアレイ / 細胞運動 / 細胞標識 / 肝臓 / 脂質代謝 |
Research Abstract |
Much about molecular mechanisms involved in regionalization of the gut endoderm remain unknown. To clarify this we isolated genes expressed in the early endoderm locally, and analyzed their function. We found that sizzled modified gradient of BMP ligand and regulated liver and stomach differentiation. Also, APOA1 induced liver endoderm at the pancreas region. In addition, the mechanism of boundary formation between the stomach and the intestine were controlled by two transcriptional factors, which are expressed in each region.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Origin of pancreatic precursors in the chick embryo and the mechanism of endoderm regionalization.2009
Author(s)
Katsumoto, K., Fukuda, K., Kimura, W., Shimamura, K., Yasugi, S., Kume, S.
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Journal Title
Mech.Dev. 126
Pages: 539-551
Related Report
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[Journal Article] Origin of pancreatic precursors in the chick embryo and the mechanism of endoderm regionalization.2009
Author(s)
Katsumoto, K., Fukuda, K., Kimura, W., Shimamura, K., Yasugi, S., Kume, S.
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Journal Title
Mechanism of Development 126
Pages: 539-551
Related Report
Peer Reviewed
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