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Regulation of odorant receptor gene expression

Research Project

Project/Area Number 20570208
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Developmental biology
Research InstitutionTokyo Institute of Technology

Principal Investigator

HIROTA Junji  Tokyo Institute of Technology, バイオ研究基盤支援総合センター, 准教授 (60405339)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords遺伝子発現調節 / 嗅覚受容体多重遺伝子 / 嗅覚 / 嗅覚受容体 / 遺伝子発現 / トランスジェニック / 神経分化
Research Abstract

To study molecular mechanisms underlying odorant receptor (OR) gene expression in mice, we have screened transcription factors which might be involved in OR gene regulation, and have made transgenic mice to identify promoter/enhancer regions. We found a few candidate factors which may regulate OR gene expression. In addition, we have constructed transgenes to identify regulatory regions OR genes, and have obtained several transgenic lines.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2010 2009 2008 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] マウス嗅覚系におけるBcl11b遺伝子発現解析2008

    • Author(s)
      榎本孝幸、木南凌、廣田順二
    • Journal Title

      日本味と匂学会誌 15(3)

      Pages: 569-572

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] マウス嗅覚系におけるBcl11b遺伝子発現解析2008

    • Author(s)
      榎本孝幸, 木南凌, 廣田順二
    • Journal Title

      日本味と匂学会誌 15

      Pages: 569-572

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bcl11b/Ctip2 controls the differentiation of vomeronasal sensory neurons in mice.

    • Author(s)
      Takayuki Enomoto, Makoto Ohmoto, Tetsuo Iwata, Ayako Uno, Masato Saitou, Tatsuya Yamaguchi, Ryo Kominami, Ichiro Matsumoto, Junji Hirota
    • Journal Title

      Journal of Neuroscience (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 嗅神経系におけるLIMホメオドメイン型転写因子Lhx2結合タンパク質の同定2010

    • Author(s)
      斎藤真人、小出裕太郎、廣田順二
    • Organizer
      第44回日本味と匂学会
    • Place of Presentation
      北九州市
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Evolution and regulation of odorant receptor genes2010

    • Author(s)
      Junji Hirota
    • Organizer
      HIT International Symposium 2010, Medical diagnostics Using Bionano Fusion Technology
    • Place of Presentation
      Ansan, Korea
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 嗅神経系におけるLIMホメオドメイン型転写因子Lhx2結合タンパク質の同定2010

    • Author(s)
      斎藤真人、小出裕太郎、廣田順二
    • Organizer
      日本味と匂学会第44回大会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of Bcl11b, C2H2 zinc finger transcription factor in the mouse olfactory system2009

    • Author(s)
      榎本孝幸, 木南凌, 廣田順二
    • Organizer
      日本味と匂学会第43回大会
    • Place of Presentation
      旭川
    • Year and Date
      2009-09-08
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス主嗅覚系におるBcl11bの機能2009

    • Author(s)
      榎本孝幸、中村亮太、畠中靖恵、木南凌、廣田順二
    • Organizer
      第43回日本と匂学会
    • Place of Presentation
      旭川市
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of Bcl11b, C2H2 zinc finger transcription factor in the mouse olfactory system2009

    • Author(s)
      T.Enomoto, R.Kominami, J.Hirota
    • Organizer
      第43回日本と匂学会
    • Place of Presentation
      旭川市
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス嗅覚系におけるBcl11bの機能2009

    • Author(s)
      榎本孝幸、木南凌、廣田順二
    • Organizer
      日本味と匂学会第43回大会
    • Place of Presentation
      旭川
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス嗅覚系におけるBclllb遺伝子発現解析2008

    • Author(s)
      榎本孝幸, 木南凌, 廣田順二
    • Organizer
      第4 2回日本味と匂学会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス嗅覚系におけるBclllb遺伝子発現解析2008

    • Author(s)
      榎本孝幸, 木南凌, 廣田順二
    • Organizer
      第31回日本神経科学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス嗅覚系におけるBcl11b遺伝子発現解析2008

    • Author(s)
      榎本孝幸、木南凌、廣田順二
    • Organizer
      日本味と匂学会第42回大会
    • Place of Presentation
      富山
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.hirota.bio,titech.ac.jp/

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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