Coupled role of Nodal and Notch in the establishment of mesodermal tissue
Project/Area Number |
20570212
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Developmental biology
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Research Institution | Rikkyo University |
Principal Investigator |
KINOSHITA Tsutomu Rikkyo University, 理学部, 教授 (30161532)
|
Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Masahiro 立教大学, 理学部, 助教 (00360660)
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Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 胚葉形成 / 原腸形成 / 体節形成 / 中胚葉形成 / Nodalシグナル / Notchシグナル / Oct25 / p27Xic1 / 中胚葉誘導 / XDeltal / Xoct25 / p27Xicl |
Research Abstract |
In early development of Xenopus embryo, Nodal signaling induces ring-shaped mesodermal tissue in the marginal zone of gastrula embryo. To understand the molecular mechanism determining the mesoderm area, transcriptional network was examined during the mesodermal formation. Several lines of experiments showed that Nodal signaling regulates the boundary formation and the cell phase transition from growth to differentiation in the mesodermal tissue by coupling with Notch signaling.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Mutation of DNA primase causes extensive apoptosis of retinal neuronS through the activation of DNA damage checkpoint and tumor suppressor p532008
Author(s)
Yamaguchi, M., Tonou-Fujimori, N., Yoshimura, Y., Kishi, T., Okamoto, H., Masai, I.
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Journal Title
Development 137(7)
Pages: 1247-57
Related Report
Peer Reviewed
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