| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Research Abstract |
MicroRNA (miRNA) gene families are shown to have evolved to alter their network configurations so that they increase the network redundancy and, in contrast, reduce their target gene repertoire. These findings suggest that a large part of the redundancy-adding role of miRNA gene families is attributable to non-adaptive processes of avoiding conflicts with the established transcription factor regulatory networks. This further indicates that the high redundancy in the miRNA regulatory networks is not necessarily a hallmark of adaptive roles such as robustness, failsafe or fine-tuning.
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