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The fitness landscape of a virus inferred based on a mathematical model of the population dynamics

Research Project

Project/Area Number 20570223
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Evolutionary biology
Research InstitutionKochi University

Principal Investigator

WATABE Teruaki  Kochi University, 教育研究部・医療学系, 講師 (90325415)

Co-Investigator(Kenkyū-buntansha) 岸野 洋久  東京大学, 農学生命科学研究科, 教授 (00141987)
Co-Investigator(Renkei-kenkyūsha) KISHINO Hirohis  東京大学, 農学生命科学研究科, 教授 (00141987)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords分子進化 / タンパク質複合体結合能 / ウイルス / 変異株 / 固定確率 / タンパク質構造 / 結合能 / アミノ酸置換 / 数理生物学 / 集団遺伝学 / ウィルス
Research Abstract

We examined how pleiotropic mutations that have antagonistic effects (i.e., antibody evasion vs. receptor binding) on viral replication within hosts can impact viral immune escape in the host population. To investigate the causal relation between a mutation in a viral genome and adaptive evolution of a viral population, we developed a mathematical model. Using population genetic theory, we evaluated the probability that a mutant is fixed in a host population. The mutations that can be fixed with high probabilities may determine how long a vaccine remains effective. We simulated the adaptive evolution of coronavirus, the etiological agent of severe acute respiratory syndrome, and showed that some of mutations may have high fixation probabilities in the vaccinated host population.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (12 results)

All 2010 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (9 results)

  • [Journal Article] Structural considerations in the fitness landscape of a virus2010

    • Author(s)
      Teruaki Watabe, Hirohisa Kishino
    • Journal Title

      Molecular Biology and Evolution 27

      Pages: 1728-1791

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural considerations in the fitness landscape of a virus2010

    • Author(s)
      Teruaki Watabe
    • Journal Title

      Molecular Biology and Evolution

      Volume: 27 Pages: 1782-1791

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural considerations in the fitness landscape of a virus2010

    • Author(s)
      Teruaki Watabe
    • Journal Title

      Molecular Biology and Evolution doi : 10.1093/molbev/msq056(印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] タンパク質にかかる多様化圧の空間分布とベイズ推定2010

    • Author(s)
      渡部輝明
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      早稲田大学(東京都)
    • Year and Date
      2010-09-07
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 局所尤度と階層ベイズによる多様化圧の空間マッピング2010

    • Author(s)
      渡部輝明
    • Organizer
      日本進化学会
    • Place of Presentation
      日本進化学会
    • Year and Date
      2010-08-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 局所尤度と階層ベイズによる多様化圧の空間マッピング2010

    • Author(s)
      渡部輝明
    • Organizer
      日本進化学会
    • Place of Presentation
      東京工業大学(東京都)
    • Year and Date
      2010-08-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] タンパク質共進化と分子進化速度の時空間変動2010

    • Author(s)
      渡部輝明
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Annual Meeting of the Society for Molecular Biology and Evolution (SMBE 2009)2009

    • Author(s)
      渡部輝明
    • Organizer
      Annual Meeting of the Society for Molecular Biology and Evolution (SMBE 2009)
    • Place of Presentation
      The University of Iowa (Iowa City, IA, U.S.A.)
    • Year and Date
      2009-06-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Structural consideration on the fitness-landscape of virus2009

    • Author(s)
      Teruaki Watabe
    • Organizer
      Annual Meetig of the Society for Molecular Biology and Evolution(SMBE 2009)
    • Place of Presentation
      The University of Iowa(Iowa City, IA, U.S.A.)
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 構造データベースに基づく複合体結合能の予測とウィルス適応度マップの構成2008

    • Author(s)
      渡部輝明
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      慶応大学(日吉)
    • Year and Date
      2008-09-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 構造データペースに基づく複合体結合能の予測とウィルス適応度マップの構成2008

    • Author(s)
      渡部輝明
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      慶応大学(日吉)
    • Year and Date
      2008-09-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 構造データベースに基づく複合体結合能の予測とウィルス適応度マップの構成2008

    • Author(s)
      渡部輝明
    • Organizer
      日本進化学会
    • Place of Presentation
      東京大学(駒場)
    • Year and Date
      2008-08-22
    • Related Report
      2010 Final Research Report 2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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