Structure and function of streptococcal system for heparin degradation/import and its involvement in infectious diseases
| Project/Area Number |
20580078
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Kyoto University |
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Principal Investigator |
HASHIMOTO Wataru Kyoto University, 大学院・農学研究科, 准教授 (30273519)
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| Research Collaborator |
MURATA Kousaku 京都大学, 大学院・農学研究科, 教授 (90142299)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 連鎖球菌 / 宿主細胞外マトリックス / グリコサミノグリカン / 多糖リアーゼ / 不飽和グルクロニルヒドロラーゼ / 侵入・感染 / X線結晶構造解析 / コンドロイチン二糖 / 硫酸化糖 / 部位特異的変異 / ファスフォトランスフェラーゼ系 / アミノ糖 / αケトグルコン酸 / DNAマイクロアレイ |
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| Research Abstract |
Pathogenic streptococci produce unsaturated glucuronyl hydrolase (UGL) together with polysaccharide lyase responsible for completely degrading glycosaminoglycans, and the streptococcal UGLs prefer sulfated substrates. This suggests that the substrate specificity is feasible for bacterial infection through degradation of mammalian extracellular matrices with sulfate groups. The motif "R-//-Sxx(S)xK" in UGL is prerequisite for degradation of sulfated substrates.
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Report
(4 results)
Research Products
(65 results)
