Biosynthes is of kasugamycin, an anti-rice blast antibiotic, in heterologous microorganisms, for the creation of hybrid antibiotics
| Project/Area Number |
20580081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Akita Prefectural University |
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Principal Investigator |
KOJIMA Ikuo 秋田県立大学, 生物資源科学部, 教授 (90315581)
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| Co-Investigator(Kenkyū-buntansha) |
AGEMATU Hitoshi 秋田高等工業専門学校, 物質工学科, 教授 (20435407)
KASUGA Kanou 秋田県立大学, 生物資源科学部, 助教 (40315594)
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| Co-Investigator(Renkei-kenkyūsha) |
IKENO Souichi 昭和薬科大学, 薬学部, 助教 (10286883)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 抗生物質生産 / 代謝工学 |
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| Research Abstract |
The biosynthetic genes of kasugamycin(KSM), anti-rice blast antibiotic, and minosaminomycin(MSM), an analogue of KSM, were cloned from their producing streptomycetes. It was found that they contained kasugamine-biosynthetic genes in common, and produced KSM and MSM heterologously when introduced via a chromosomal integration vector. In addition, specific parts of MSM biosynthetic genes induced heterologous production of unknown antibiotic(s). These results seem to suggest that suitable combination of these biosynthetic genes enables to produce new antibiotic(s).
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Report
(4 results)
Research Products
(9 results)
