Development of vacuole-targeting antifungal chemotherapy for suicide induction
| Project/Area Number |
20580083
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Osaka City University |
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Principal Investigator |
TANAKA Toshio Osaka City University, 大学院・理学研究科, 教授 (10137185)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | amphotericin B / polymyxin B / 選択的抗真菌作用 / allicin / 液胞破壊 / 選択毒性 / Candida albicans / amphoterisin B / zwiebelane / 液胞破壞作用 / アリシン / アンホテリシンB / 抗真菌作用 / 液胞 / エルゴステロール / 出芽酵母 / ポリミキシンンB / タマネギ |
|---|
| Research Abstract |
The vacuole-disruptive activities of amphotericin B and polymyxin B were evaluated as novel types of fungicidal actions, and their mechanisms have been partly elucidated. This study also found allicin from garlic and zwiebelan from onion as enhancers of vacuole-targeting fungicidal activities of these antifungal agents, and thus proposes enzymatic production of allicin as a substitute for its production by the chemical reaction. A system has been additionally proposed for practically applying the chemotherapy depending on the vacuole-targeting fungicidal activities.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Alliinase from Ensifer adhaerence and its use for generation of fungicidal activity.2011
Author(s)
Yutani, M., Taniguchi, H., Borjihan, H., Ogita, A., Fujita, K., Tanaka, T.
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Journal Title
AMB Express Vol.1
Pages: 1-8
Related Report
Peer Reviewed
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[Journal Article] Synergisitic fungicidal activities of polymyxin B and ionophores, and their dependence on direct disruptive action of polymyxin B on fungal vacuole.2009
Author(s)
Ogita, A., Konishi, Y., Borjihan, B., Fujita, K., Tanaka, T.
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Journal Title
J. Antibiotics Vol.62
Pages: 81-87
Related Report
Peer Reviewed
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[Journal Article] Synergisitic fungicidal activity of polymyxin B and ionophores, and their dependence on direct disruptive action of polymxinn B on fungal vacuole2009
Author(s)
Ogita, A., Konishi, Y., Borjihan, B., Fujita, K., Tanaka, T
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Journal Title
Journal of Antibiotics 62
Pages: 81-87
Related Report
Peer Reviewed
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