| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
The vacuole-disruptive activities of amphotericin B and polymyxin B were evaluated as novel types of fungicidal actions, and their mechanisms have been partly elucidated. This study also found allicin from garlic and zwiebelan from onion as enhancers of vacuole-targeting fungicidal activities of these antifungal agents, and thus proposes enzymatic production of allicin as a substitute for its production by the chemical reaction. A system has been additionally proposed for practically applying the chemotherapy depending on the vacuole-targeting fungicidal activities.
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