The molecular mechanism underlying the co-regulation of plasma membrane and F-actin
Project/Area Number |
20580096
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied biochemistry
|
Research Institution | The University of Tokyo |
Principal Investigator |
IHARA Sayoko 東京大学, 大学院・農学生命科学研究科, 助教 (80292788)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 細胞応答 / 細胞骨格 / 細胞膜 / アクチン / アクチ |
Research Abstract |
Cells change their morphology under various physiological conditions. Co-regulation of plasma membrane and cytoskeleton is required for these changes, the mechanism of which is not fully understood. We addressed the issue by functional analysis of SWAP-70, which binds to both membrane and actin in a stimulus-dependent way. We found that SWAP-70 binds to integrin. 1 in a pull down assay, and the activation of integrin. 1 rescued SWAP-70-deficient phenotype, suggesting that SWAP-70 may function by activating integrin. 1 through their interaction.
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Report
(4 results)
Research Products
(7 results)