| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Skeletal muscle, the largest organ in the human body, plays roles in energy expenditure, glucose uptake and exercise. Here, we show that FOXO1 enhances gene expression of cathepsin L, a lysosomal proteinase, in vivo and in vitro. Our data indicate that cathepsin L is a direct target of FOXO1 in the skeletal muscle and suggest that the FOXO1/cathepsin L pathway plays a role in diabetes and starvation-induced skeletal muscle metabolic change and atrophy. Also, we investigated the glucose metabolism of RXRγ mice with induced obesity and impaired glucose metabolism. The data showed that increased glucose uptake in the skeletal muscle improved systemic glucose metabolism, and increasing RXRγ expression may be a novel therapeutic strategy against impaired glucose metabolism caused by obesity.
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