Elucidation of molecular mechanism of skeletal muscle function, focusing on transcription factors
| Project/Area Number |
20580097
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KAMEI Yasutomi Tokyo Medical and Dental University, 難治疾患研究所, 准教授 (70300829)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 代謝生理 / 骨格筋 / 糖脂質代謝 / 核内受容体 / 転写調節 / 糖尿病 / 筋萎縮 / 筋肉内脂肪 / 肥満 / インスリン / 生活習慣病 |
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| Research Abstract |
Skeletal muscle, the largest organ in the human body, plays roles in energy expenditure, glucose uptake and exercise. Here, we show that FOXO1 enhances gene expression of cathepsin L, a lysosomal proteinase, in vivo and in vitro. Our data indicate that cathepsin L is a direct target of FOXO1 in the skeletal muscle and suggest that the FOXO1/cathepsin L pathway plays a role in diabetes and starvation-induced skeletal muscle metabolic change and atrophy. Also, we investigated the glucose metabolism of RXRγ mice with induced obesity and impaired glucose metabolism. The data showed that increased glucose uptake in the skeletal muscle improved systemic glucose metabolism, and increasing RXRγ expression may be a novel therapeutic strategy against impaired glucose metabolism caused by obesity.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] The cathepsin L gene is a direct target of FOXO1 in the skeletal muscle.2010
Author(s)
Y.Yamazaki, Y.Kamei, S.Sugita, F.Akaike, S.Kanai, S.Miura, Y.Hirata, B.R.Troen, T.Kitamura, I.Nishino, T.Suganami, O.Ezaki, Y.Ogawa.
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Journal Title
Biochemical Journal 427(Corresponding author)
Pages: 171-178
Related Report
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[Journal Article] A novel glycerophosphodiester phosphodiesterase GDE5 controls skeletal muscle development via a non-enzymatic mechanism.2010
Author(s)
Y.Okazaki, N.Ohshima, I.Yoshizawa, Y.Kamei, S.Mariggio, K.Okamoto, M.Maeda, Y.Nogusa, Y.Fujioka, T.Izumi, Y.Ogawa, Y.Shiro, M.Wada, N.Kato, D.Corda, N.Yanaka.
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Journal Title
Journal of Biological Chemistry 285
Pages: 27652-27663
Related Report
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[Journal Article] The cathepsin L gene is a direct target of FOXO1 in the skeletal muscle.2010
Author(s)
Y.Yamazaki, Y.Kamei, S.Sugita, F.Akaike, S.Kanai, S.Miura, Y.Hirata, B.R.Troen, T.Kitamura, I.Nishino, T.Suganami, O.Ezaki, Y.Ogawa.
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Journal Title
Biochem.J
Volume: 427
Pages: 171-178
Related Report
Peer Reviewed
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[Journal Article] Anovel glycerophosphodiester phosphodiesterase GDE5 controls skeletal muscle development via a non-enzymatic mechanism.2010
Author(s)
Y.Okazaki, N.Ohshima, I.Yoshizawa, Y.Kamei, S.Mariggio, K.Okamoto, M.Maeda, Y.Nogusa, Y.Fujioka, T.Izumi, Y.Ogawa, Y.Shiro, M.Wada, N.Kato, D.Corda, N.Yanaka.
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Journal Title
Journal of Biological Chemistry
Volume: 285
Pages: 27652-27663
Related Report
Peer Reviewed
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