Physiological functions of novel mammalian glycerophosphodiester phosphodiesterases
| Project/Area Number |
20580098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
YANAKA Noriyuki Hiroshima University, 大学院・生物圏科学研究科, 准教授 (70346526)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Norihisa 広島大学, 大学院・生物圏科学研究科, 教授 (20144892)
WADA Masanobu 広島大学, 大学院・総合科学研究科, 教授 (80220961)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMEI Yasutomi 東京医科歯科大学, 難治疾患研究所, 准教授 (70300829)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | glycerophosphodiester phosphodiesterase / glycerophosphocholine / glycerophosphoinositol / differentiation / skeletal muscle / atrophy / グリセロリン脂質 / 骨格筋 / 萎縮 / 遺伝子 / 腸管 / 上皮細胞 |
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| Research Abstract |
This study isolated a novel GP-PDE, GDE5, and showed that GDE5 selectively hydrolyzes glycerophosphocholine (GroPCho). We show that that decreasing GDE5 abundance promoted myoblastic differentiation. Furthermore, transgenic mice specifically expressing GDE5 in skeletal muscle showed less skeletal muscle mass, especially type II fiber-rich muscle. These results indicate that GDE5 negatively regulates skeletal muscle development, providing novel insight into the biological significance of mammalian GP-PDE functions.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] A novel glycerophosphodiester phosphodiesterase GDE5 controls skeletal muscle development via a non-enzymatic mechanism.2010
Author(s)
Okazaki Yuri, Ohshima Noriyasu, Yoshizawa Ikumi, Kamei Yasutomi, Mariggio Stefania, Okamoto Keiko, Maeda Masahiro, Nogusa Yoshihito, Fujioka Yuichiro, Izumi Takashi, Ogawa Yoshihiro, Shiro Yoshitsugu, Wada Masanobu, Kato Norihisa, Corda Daniela, Yanaka Noriyukui
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Journal Title
J.Biol.Chem. 285
Pages: 27652-27663
Related Report
Peer Reviewed
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[Presentation] 新規因子GDE5の筋芽細胞分化における役割,および骨格筋特異的GDE5過剰発現マウスの形質の解析2009
Author(s)
岡本佳子, 吉澤郁美, 大嶋紀安, 亀井康富, 岡崎優利, 前田将宏, 和泉孝志, 加藤範久, 和田正信, 矢中規之
Organizer
2009年度日本農芸化学会大会
Place of Presentation
福岡
Year and Date
2009-03-28
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