| Project/Area Number |
20580098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
YANAKA Noriyuki Hiroshima University, 大学院・生物圏科学研究科, 准教授 (70346526)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Norihisa 広島大学, 大学院・生物圏科学研究科, 教授 (20144892)
WADA Masanobu 広島大学, 大学院・総合科学研究科, 教授 (80220961)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMEI Yasutomi 東京医科歯科大学, 難治疾患研究所, 准教授 (70300829)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | glycerophosphodiester phosphodiesterase / glycerophosphocholine / glycerophosphoinositol / differentiation / skeletal muscle / atrophy / グリセロリン脂質 / 骨格筋 / 萎縮 / 遺伝子 / 腸管 / 上皮細胞 |
|---|
| Research Abstract |
This study isolated a novel GP-PDE, GDE5, and showed that GDE5 selectively hydrolyzes glycerophosphocholine (GroPCho). We show that that decreasing GDE5 abundance promoted myoblastic differentiation. Furthermore, transgenic mice specifically expressing GDE5 in skeletal muscle showed less skeletal muscle mass, especially type II fiber-rich muscle. These results indicate that GDE5 negatively regulates skeletal muscle development, providing novel insight into the biological significance of mammalian GP-PDE functions.
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