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Physiological functions of novel mammalian glycerophosphodiester phosphodiesterases

Research Project

Project/Area Number 20580098
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied biochemistry
Research InstitutionHiroshima University

Principal Investigator

YANAKA Noriyuki  Hiroshima University, 大学院・生物圏科学研究科, 准教授 (70346526)

Co-Investigator(Kenkyū-buntansha) KATO Norihisa  広島大学, 大学院・生物圏科学研究科, 教授 (20144892)
WADA Masanobu  広島大学, 大学院・総合科学研究科, 教授 (80220961)
Co-Investigator(Renkei-kenkyūsha) KAMEI Yasutomi  東京医科歯科大学, 難治疾患研究所, 准教授 (70300829)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsglycerophosphodiester phosphodiesterase / glycerophosphocholine / glycerophosphoinositol / differentiation / skeletal muscle / atrophy / グリセロリン脂質 / 骨格筋 / 萎縮 / 遺伝子 / 腸管 / 上皮細胞
Research Abstract

This study isolated a novel GP-PDE, GDE5, and showed that GDE5 selectively hydrolyzes glycerophosphocholine (GroPCho). We show that that decreasing GDE5 abundance promoted myoblastic differentiation. Furthermore, transgenic mice specifically expressing GDE5 in skeletal muscle showed less skeletal muscle mass, especially type II fiber-rich muscle. These results indicate that GDE5 negatively regulates skeletal muscle development, providing novel insight into the biological significance of mammalian GP-PDE functions.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (31 results)

All 2011 2010 2009 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (18 results) Book (1 results) Remarks (1 results)

  • [Journal Article] A novel glycerophosphodiester phosphodiesterase GDE5 controls skeletal muscle development via a non-enzymatic mechanism.2010

    • Author(s)
      Okazaki Yuri, Ohshima Noriyasu, Yoshizawa Ikumi, Kamei Yasutomi, Mariggio Stefania, Okamoto Keiko, Maeda Masahiro, Nogusa Yoshihito, Fujioka Yuichiro, Izumi Takashi, Ogawa Yoshihiro, Shiro Yoshitsugu, Wada Masanobu, Kato Norihisa, Corda Daniela, Yanaka Noriyukui
    • Journal Title

      J.Biol.Chem. 285

      Pages: 27652-27663

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of eccentric contraction on myofibrillar proteins in rat skeletal muscle.2010

    • Author(s)
      Kanzaki Keita, Kuratani Mai, Mishima Takaaki, Matsunaga Satoshi, Yanaka Noriyuki, Usui Sachio, Wada Masanobu
    • Journal Title

      Eur.J.Appl.Physiol. 110

      Pages: 943-952

    • NAID

      120002753733

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of curcumin on IMP dehydrogenase, the target for anticancer and antiviral chemotherapy agents.2010

    • Author(s)
      Dairaku Issei, Han Yunkyung, Yanaka Noriyuki, Kato Norihisa
    • Journal Title

      Biosci. Biotechnol. Biochem. 4

      Pages: 185-187

    • NAID

      10027550621

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 膜由来の新しいシグナル伝達物質グリセロホスホジエステルの生理的な役割2010

    • Author(s)
      矢中規之, 本田絢子
    • Journal Title

      化学と生物 48

      Pages: 812-814

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel glycerophosphodiester phosphodiesterase GDE5 controls skeletal muscle development via a non-enzymatic mechanism.2010

    • Author(s)
      Yuri Okazaki, ら
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 27652-27663

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of eccentric contraction on myofibrillar proteins in rat skeletal muscle.2010

    • Author(s)
      Keita Kanzaki, ら
    • Journal Title

      Eur.J.Appl.Physiol

      Volume: 110 Pages: 943-952

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The developmentally regulated osteoblast phosphodiesterase GDE3 is glycerophosphoinositol-specific and modulates cell growth.2009

    • Author(s)
      Corda Daniela, Kudo Takahiro, Zizza Pasquale, Iurisci Cristiano, Kawai Eri, Kato Norihisa, Yanaka Noriyuki, Mariggio Stefania
    • Journal Title

      J.Biol.Chem. 284

      Pages: 24848-24856

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generation of a zinc finger protein ZPR1 mutant that constitutively interacted with translation elongation factor lalpha.2009

    • Author(s)
      Yanaka Noriyuki, Kaseda Yurika, Tanaka Anna, Nogusa Yoshihito, Sumiyoshi Naoki, Kato Norihisa
    • Journal Title

      Biosci. Biotechnol. Biochem. 73

      Pages: 2809-2811

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.2009

    • Author(s)
      Hirata Toshifumi, Fujii Misato, Akita Kazuhiro, Yanaka Noriyuki, Ogawa Kaori, Kuroyanagi Masanori, Hongo Daiki
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 25-28

    • NAID

      120002771002

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The developmentally regulated osteoblast phosphodiesterase GDE3 is glvcerophosphoinositol-specific and modulates cell growth.2009

    • Author(s)
      Daniela Corda, ら
    • Journal Title

      J.Biol.Chem.

      Volume: 284 Pages: 24848-24856

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of a zinc finger protein ZPR1 mutant that constitutively interacted with translation elongation factor lalpha.?2009

    • Author(s)
      Noriyuki Yanaka, ら
    • Journal Title

      Biosci.Biotechnol.Biochem.

      Volume: 73 Pages: 2809-2811

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Vitamin B6の摂取が脂肪組織の遺伝子発現に及ぼす影響2011

    • Author(s)
      真田洋平, 矢中規之, 末廣春奈, 久本高央, 平田敦子, 西村英紀, 加藤範久
    • Organizer
      2011年度日本農芸化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] リン脂質代謝酵素GDE5の発現抑制による筋芽細胞株C2C12細胞の筋分化誘導の機構解析2011

    • Author(s)
      岡本佳子, 中村啓司, 吉澤郁美, 吉田円, 栗崎知浩, 加藤範久, 矢中規之
    • Organizer
      2011年度日本農芸化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-26
    • Related Report
      2010 Final Research Report
  • [Presentation] リン脂質代謝酵素GDE5の発現抑制による筋芽細胞株C2C12細胞の筋分化誘導の機構解析2011

    • Author(s)
      岡本佳子, ら
    • Organizer
      日本農芸化学会大会2011
    • Place of Presentation
      京都市
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] azoxymethane誘発大腸腫瘍モデルマウスの初期病変に関わる新規標的因子の同定2010

    • Author(s)
      平田敦子, 真田洋平, 末廣春奈, 大畑智美, 矢中規之, 加藤範久
    • Organizer
      および抗癌活性を有するvitaminB6の予防効果に関する解析第33回日本分子生物学会年会 第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] azoxymethane誘発大腸腫瘍モデルマウスの初期病変に関わる新規標的因子の同定、および抗癌活性を有するvitamin B6の予防効果に関する解析2010

    • Author(s)
      平田敦子, ら
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規リン脂質代謝酵素GDE5のC2C12細胞の筋分化における役割2010

    • Author(s)
      前田将宏, 吉澤郁美, 岡本佳子, 栗崎知浩, 加藤範久, 矢中規之
    • Organizer
      2010年度日本農芸化学会大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 消化管上皮細胞機能に関わるglycerophosphoinositolの分解酵素の探索2010

    • Author(s)
      本田絢子, 工藤尊裕, 山下洋祐, 岩永敏彦, Stefania Mariggio, Daniela Corda, 加藤範久, 矢中規之
    • Organizer
      2010年度日本農芸化学会大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] ビタミンB6摂取による大腸における遺伝子発現調節作用2010

    • Author(s)
      大畑智美, 矢中規之, 平田敦子, 真田洋平, 末廣春奈, 鳥家圭悟, 加藤範久
    • Organizer
      2010年度日本農芸化学会大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規リン脂質代謝酵素GDE5のC2C12細胞の筋分化における役割2010

    • Author(s)
      前田将宏, ら
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 消化管上皮細胞機能に関わるglycerophosphoinositolの分解酵素の探索2010

    • Author(s)
      本田絢子, ら
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 筋芽細胞分化中の新規グリセロホスホジエステルホスホジエステラーゼGDE5の機能的役割2009

    • Author(s)
      吉澤郁美, 岡本佳子, 前田将宏, 岡崎優利, 大嶋紀安, 和泉孝志, 加藤範久, 矢中規之
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] ビタミンB6摂取により大腸で発現上昇するLamininγ2の単離,および発現調節機構の解明2009

    • Author(s)
      末廣春奈, 鳥家圭悟, 大畑智美, 矢中規之, 加藤範久
    • Organizer
      2009年度日本農芸化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 魚油摂取によってラットの大脳皮質で発現上昇するAlas2遺伝子の単2009

    • Author(s)
      江口優子, 平田敦子, 原口智彰, 工藤尊裕, 矢中規之, 加藤範久
    • Organizer
      2009年度日本農芸化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規因子GDE5の筋芽細胞分化における役割,および骨格筋特異的GDE5過剰発現マウスの形質の解析2009

    • Author(s)
      岡本佳子, 吉澤郁美, 大嶋紀安, 亀井康富, 岡崎優利, 前田将宏, 和泉孝志, 加藤範久, 和田正信, 矢中規之
    • Organizer
      2009年度日本農芸化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 細胞骨格調節因子GDE3による細胞球状化のメカニズムに関する解析2009

    • Author(s)
      工藤尊裕, Stefania Mariggio, 本田絢子, 河合衣里, 加藤範久, Daniela Corda, 矢中規之
    • Organizer
      2009年度日本農芸化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 消化管のビタミンB6代謝の特性2009

    • Author(s)
      具正愛, 田中健太, 矢中規之, 加藤範久
    • Organizer
      2009年度日本農芸化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規因子GDE5の筋芽細胞分化における役割、および骨格筋特異的GDE5過剰発現マウスの形質の解析2009

    • Author(s)
      矢中 規之
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      マリンメッセ福岡
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞骨格調節因子GDE3による細胞球状化のメカニズムに関する解析2009

    • Author(s)
      矢中 規之
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      マリンメッセ福岡
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Book] 化学と生物2010

    • Author(s)
      矢中規之, ら
    • Total Pages
      3
    • Publisher
      学会出版センター
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://home.hiroshima-u.ac.jp/nutri/yanakaN.htm

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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