| Project/Area Number |
20580102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
KOJOMA Mareshige Health Sciences University of Hokkaido, 薬学部, 准教授 (80342781)
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| Co-Investigator(Kenkyū-buntansha) |
SEKI Hikaru 大阪大学, 工学研究科, 准教授 (30392004)
寺崎 将 北海道医療大学, 薬学部, 講師 (10391195)
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| Co-Investigator(Renkei-kenkyūsha) |
TERASAKI Masaru 北海道医療大学, 薬学部, 講師 (10391195)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | カンゾウ / 甘草 / グリチルリチン / 物質生産 / 生合成 / トリテルペノイド / グリチルリチ |
|---|
| Research Abstract |
Glycyrrhizae Radix, the underground material derived from Glycyrrhiza uralensis is extensively used as an herbal medicine in worldwide. Biological activities of licorice have been attributed to glycyrrhizin (a triterpenoid compound). It is important to up-regulate the production of glycyrrhizin in G. uralensis. In this study, we clarified the gene regulation of glycyrrhizin biosynthesis, and develop a basic technique for the producing glycyrrhizin in the cultured cells.
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