| Project/Area Number |
20580103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Keio University |
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Principal Investigator |
WATANABE Mitsuhiro Keio University, 医学部, 准教授 (10450842)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TANIGAWARA Yusuke 慶應義塾大学, 医学部, 教授 (30179832)
ITOH Hiroshi 慶應義塾大学, 医学部, 教授 (40252457)
MORIMOTO Kokichi 慶應義塾大学, 医学部, 助教 (10468506)
SUGIZAKI Taichi 慶應義塾大学, 医学部, 助教 (00468480)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 代謝 / 糖尿病 / 胆汁酸 / 核内受容体 / 生活習慣病 / エネルギー代謝 / オミックス解析 |
|---|
| Research Abstract |
Administration of FXR agonist accentuated body weight gain and glucose intolerance induced by the high fat diet and led to a pronounced worsening of the changes in liver and adipose tissue. Mechanistically, treatment with FXR agonist decreased BA biosynthesis, BA pool size and energy expenditure. Our data hence suggest that activation of FXR with synthetic agonists is not useful for long term management of the metabolic syndrome, as it reduces the BA pool size and subsequently decreases energy expenditure, translating in weight gain and insulin resistance. In addition, it was suggested that bile acid participated in amino acid metabolism in energy homeostasis by DNA micro array and metabolome analysis.
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