Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Research Abstract |
Bone continuously undergoes remodeling, in which bone resorption by osteoclasts is followed by bone formation by osteoblasts, and maintains its structure and function. An imbalance in the regulation of bone remodeling results in many metabolic bone diseases, such as osteoporosis. Here we show that a low molecular weight compound which specifically activates protein phosphatase 2C(PP2C)suppressed osteoclastogenesis, and how it acts on the RANKL induced osteoclast differentiation.
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