Improve the specificity of a PrP^<Sc>-degrading enzyme and application for industry
| Project/Area Number |
20580106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Kyushu Sangyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Masatoshi 九州大学, 農学研究院, 寄付講座教員 (90274521)
OKA Tatsuzo 鹿児島大学, 農学部, 教授 (50116795)
KANOUCHI Hiroaki 鹿児島大学, 農学部, 准教授 (10351884)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 異常プリオン / ケラチナーゼ / プロテアーゼ / ケラチン |
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| Research Abstract |
The region concluding Arg 117 and 133 of NAPase had the keratin adsorbability, and was concerned with PrP^<Sc>-degrading activity. The specificity to hard-to-degrading protein of NAPase was improved by random mutagenesis. A specific inhibitor of NAPase adaptable for meet cleaner was discovered from bitter gourd.
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Report
(6 results)
Research Products
(27 results)
