Elucidation of control mechanism of spore germination in microorganisms by self-germination inhibitors of actinomycetes.

• Project/Area Number: 20580109
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bioproduction chemistry/Bioorganic chemistry
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: NATSUME Masahiro Tokyo University of Agriculture and Technology, 大学院・農学研究院, 教授 (10201683)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: Streptomyces coelicolor / Streptomyces griseus / Streptomyces viridochromogenes / germicidin / hypnosin / 放線菌 / 発芽抑制物質

Research Abstract

Four germicidins were isolated from Streptomyces coelicolor. Their germination inhibitory activity and contents in spores revealed that germicidins function as self-germination inhibitors. Reexamination in S. viridochromogenes indicated that the major self-germination inhibitor was found to be an EtOAc-soluble neutral substance. The similar inhibitor was also produced by S.griseus.

Research Products

• [Journal Article] Physiological role of germicidins in spore germination and hyphal elongation in Streptomyces coelicolor A3(2)
  • Author(s): Yuu Aoki, Daisuke Matsumoto, Hiroshi Kawaide, Masahiro Natsume
  • Journal Title: The Journal of Antibiotics 掲載決定
  • NAID: 10030640058
  • Peer Reviewed
• [Presentation] 放線菌Streptomyces coelicolorの自己胞子発芽抑制物質 (2010)
  • Author(s): 夏目雅裕, ら
  • Organizer: 日本農薬学会第35回大会
  • Place of Presentation: 札幌市
  • Year and Date: 2010-05-29
• [Presentation] 放線菌の自己胞子発芽抑制物質(第5報)-Germicidin の働き- (2008)
  • Author(s): 青木友, ら
  • Organizer: 2008年度日本放線菌学会大会
  • Place of Presentation: 山梨市
  • Year and Date: 2008-07-10
• [Presentation] 放線菌の自己胞子発芽抑制物質(第5報)-Germicidinの働き- (2008)
  • Author(s): 夏目雅裕
  • Organizer: 2008年度日本放線菌学会大会
  • Place of Presentation: 山梨県山梨市
• [Remarks] ホームページ等
  • URL: http://www.tuat.ac.jp/~chemreg/research/spore.html
• [Remarks]
  • URL: http://www.tuat.ac.jp/~chemreg/research/spore.html
• [Remarks]
  • URL: http://www.tuat.ac.jp/~chemreg/research/spore.html
• [Remarks]
  • URL: http://www.tuat.ac.jp/~chemreg/research/spore.html