Synthetic and bioorganic studies on sarcodonins
Project/Area Number |
20580110
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Bioproduction chemistry/Bioorganic chemistry
|
Research Institution | Shinshu University |
Principal Investigator |
MAKABE Hidefumi Shinshu University, 農学研究科, 准教授 (90313840)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 有機化学 / 合成化学 / 生理活性 |
Research Abstract |
Synthetic studies on sarcodonin J and structural activity relationship study on sarcodonin A related compounds were performed. As to the synthetic study on sarcodonin J, synthetic route was almost accomplished using Negishi coupling starting from (-)-Wieland-Miescher ketone. As to the structural activity relationship study on sarcodonin A related compounds, the hydroxyl group at C-14 position proved to be extremely important for the anti-inflammatory activity.
|
Report
(4 results)
Research Products
(4 results)