| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Synthetic studies on sarcodonin J and structural activity relationship study on sarcodonin A related compounds were performed. As to the synthetic study on sarcodonin J, synthetic route was almost accomplished using Negishi coupling starting from (-)-Wieland-Miescher ketone. As to the structural activity relationship study on sarcodonin A related compounds, the hydroxyl group at C-14 position proved to be extremely important for the anti-inflammatory activity.
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