• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Chemical Biology of lifespan-extending substrates secreted by the nematode Caenorhabditis elegans

Research Project

Project/Area Number 20580112
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioproduction chemistry/Bioorganic chemistry
Research InstitutionTottori University

Principal Investigator

KAWANO Tsuyoshi  Tottori University, 農学部, 教授 (50270567)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords寿命 / 休眠 / インスリン / 線虫 / 発現制御 / 情報分子 / ペプチドホルモン / 寿命制御 / シグナル伝達
Research Abstract

I have identified Caenorhabditis elegans insulin-like genes ins-6, ins-12, and ins-35. Expression of these genes was regulated by lifespan-extending substances secreted by C.elegans. Gene-disruption revealed that ins-6 and ins-12 were relevant to regulation of lifespan. In contrast, ins-35 was largely relevant to regulation of larval diapause not adult lifespan. In addition, analyses of expression patterns of ins-35 allowed me to understand the physiological function of the gene.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009 2008 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (16 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] An altered method of feeding RNAi that knocks down multiple genes simultaneously in the nametode Caenorhabditis elegans.2010

    • Author(s)
      Gouda K, Matsunaga Y, Iwasaki T, an Kawano T
    • Journal Title

      Biosci.Biotechnol.Biochem. 74

      Pages: 2361-2365

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physiological function of INS-12, one of the Type-γ insulin-like peptides2010

    • Author(s)
      Matsunaga Y, Ito H, Kawano T
    • Journal Title

      in C.elegans.Peptide Science

      Pages: 459-462

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] An altered method of feeding RNAi that knocks down multiple genes simultaneously in the nametode Caenorhabditis elegans2010

    • Author(s)
      Gouda K, Matsunaga Y, Iwasaki T, Kawano T
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 74 Pages: 2361-2365

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiological function of INS-12, one of the Type-g insulin-like peptides, in C. elegans2010

    • Author(s)
      Matsunaga, Y., Ito, H., Kawano, T.
    • Journal Title

      Peptide Science

      Pages: 459-462

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiological function of type-β insulin-like genes2008

    • Author(s)
      Yonezawa Y, Kimura Y, Kawano T
    • Journal Title

      in C.elegans.Peptide Science

      Pages: 525-528

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physiological function of type-β・insulin-like genes in C. elegans2008

    • Author(s)
      Yonezawa, Y., Kimura, Y., Kawano, Y
    • Journal Title

      Peptide Science

      Pages: 525-528

    • NAID

      10021906926

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nematicidal activity of actylene compounds from Co repsis lanceolara L.2008

    • Author(s)
      Kimura, Y., Kawano, T., Fujioka, S., Shimada, A.
    • Journal Title

      Z. Naturforsch[C] 6

      Pages: 843-847

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 線虫C.elegansの幼虫休眠を制御するインスリン様ペプチドINS-352011

    • Author(s)
      片山侑希、阪本晃市、河野佳世、松永洋平、岩崎崇、河野強
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 線虫C.elegansのインスリン様ペプチドINS-18の発現制御機構2011

    • Author(s)
      松永洋平、玄行・安藤恵子、三谷昌平、岩崎崇、河野強
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 線虫C.elegansの幼虫休眠を制御するインスリン様ペプチドINS-352011

    • Author(s)
      片山侑希、阪本晃市、河野佳世、松永洋平、岩崎崇、河野強
    • Organizer
      日本農芸化学会2011年度大学
    • Place of Presentation
      京都女子大(京都)
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 線虫C.elegansのインスリン様ペプチドINS-18の発現制御機構2011

    • Author(s)
      松永洋平、玄行・安藤恵子、三谷昌平、岩崎崇、河野強
    • Organizer
      日本農芸化学会2011年度大学
    • Place of Presentation
      京都女子大(京都)
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] An approach to elucidate crosstalk between TGF-b and insulin/IGF-I signaling in Caenorhabditis elegans.2010

    • Author(s)
      松永洋平, 安藤-玄行恵子, 三谷昌平, 岩崎崇, 河野佳世
    • Organizer
      4th East Asia C.elegans Meeting
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2010-06-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Analysis of a new pathway regulating larval diapuase in Caenorhabditis elegans.2010

    • Author(s)
      Yukari Omichi, Kenji Gouda, Takashi Iwasaki, Tsuyoshi Kawano
    • Organizer
      4th East Asia C.elegans Meeting
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2010-06-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Analysis of a new pathway regulating larval diapause in Caenorhabditis elegans2010

    • Author(s)
      Omichi Y, Gouda K, Iwasaki T, Kawano T
    • Organizer
      4^<th> East Asia C.elegans Meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] An approach to elucidate crosstalk between TGF-β and insulin/IGF-1 signaling in Caenorhabditis elegans2010

    • Author(s)
      Matsunaga Y, Gengyo-Ando K, Mitani S, Iwasaki T, Kawano T
    • Organizer
      4^<th> East Asia C.elegans Meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 線虫C.elegansのtype-γインスリン様ペプチドであるINS-12の生理学的機能2009

    • Author(s)
      松永洋平、伊藤弘子、河野強
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州
    • Year and Date
      2009-11-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Expression mechanism of INS-18, one of the insulin-like peptides, in C.elegans2009

    • Author(s)
      Yohei Matsunaga, Keiko Gengyo-Ando, Shohei Mitani, Tsuyosi Kawano
    • Organizer
      17th International C.elegans Meeting
    • Place of Presentation
      University of California, Los Angeles, USA
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Expression mechanism of INS-18, one of the insulin-like peptides, in C.elegans.2009

    • Author(s)
      Yohei Matsunaga, KeikoGengyo-Ando, Shohei Mitani, Tsuyoshi Kawano
    • Organizer
      17th International C.elegans Meeting
    • Place of Presentation
      Los Angeles, USA
    • Year and Date
      2009-06-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 線虫におけるインスリン様遺伝子の機能解析2009

    • Author(s)
      松永洋平, 伊藤弘子, 河野 強
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 線虫の休眠・寿命を制御するインスリン様ペプチド2009

    • Author(s)
      松永洋平、安藤-玄行恵子、三谷昌平、河野強
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 線虫C.elegansにおける簡便な三重遺伝子機能抑制法2008

    • Author(s)
      合田健司、河野強
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 線虫の休眠・寿命を制御するインスリン様ペプチドINS-18の発現調節機構2008

    • Author(s)
      松永洋平、安藤-玄行恵子、三谷昌平、河野強
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 線虫C. elegansのインスリン様分子INS-18の発現制御機構2008

    • Author(s)
      松永洋平, 安藤恵子, 三谷昌平, 河野 強
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://staff.muses.tottori-u.acjp/kawano/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://staff.muses.tottori-u.ac.jp/kawano/

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] ネコブセンチュウpos-1遺伝子、及びその遺伝子発現制御によるネコブセンチュウ防除方法2009

    • Inventor(s)
      河野強
    • Industrial Property Rights Holder
      河野強
    • Filing Date
      2009-10-13
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] ネコブセンチュウpos-1遺伝子、及びその遺伝子発現制御によるネコブセンチュウ防除方法2009

    • Inventor(s)
      河野強
    • Industrial Property Rights Holder
      鳥取大学
    • Industrial Property Number
      2009-236075
    • Filing Date
      2009-10-13
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi