Chemical Biology of lifespan-extending substrates secreted by the nematode Caenorhabditis elegans
Project/Area Number |
20580112
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Bioproduction chemistry/Bioorganic chemistry
|
Research Institution | Tottori University |
Principal Investigator |
KAWANO Tsuyoshi Tottori University, 農学部, 教授 (50270567)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 寿命 / 休眠 / インスリン / 線虫 / 発現制御 / 情報分子 / ペプチドホルモン / 寿命制御 / シグナル伝達 |
Research Abstract |
I have identified Caenorhabditis elegans insulin-like genes ins-6, ins-12, and ins-35. Expression of these genes was regulated by lifespan-extending substances secreted by C.elegans. Gene-disruption revealed that ins-6 and ins-12 were relevant to regulation of lifespan. In contrast, ins-35 was largely relevant to regulation of larval diapause not adult lifespan. In addition, analyses of expression patterns of ins-35 allowed me to understand the physiological function of the gene.
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Report
(4 results)
Research Products
(27 results)