Liquid-phase combinatorial synthesis of biologically active peptides utilizing fluorous tag
Project/Area Number |
20580115
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Bioproduction chemistry/Bioorganic chemistry
|
Research Institution | Meijo University |
Principal Investigator |
|
Project Period (FY) |
2008 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | フルオラス / 液相コンビナトリアル合成 / 生理活性 / ペプチド / フルオラスタグ / コンビナトリアル合成 / 液相 / ミクスチャー合成 |
Research Abstract |
A study to carry out a concise liquid combinatorial synthesis of bioactive peptides, which was encoded by fluorous tag, was conducted. We have developed a highly active condensation reagent for peptides coupling, and a large-scale synthetic method of the fluorous protecting-reagent for amino acids. Furthermore, a synthetic route of Tenuecyclamide B from the N-terminus was established for the liquid mixture synthesis of the all stereoisomers.
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Report
(6 results)
Research Products
(56 results)