| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
A study to carry out a concise liquid combinatorial synthesis of bioactive peptides, which was encoded by fluorous tag, was conducted. We have developed a highly active condensation reagent for peptides coupling, and a large-scale synthetic method of the fluorous protecting-reagent for amino acids. Furthermore, a synthetic route of Tenuecyclamide B from the N-terminus was established for the liquid mixture synthesis of the all stereoisomers.
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