A new method for analysis of stereochemistry in carbonyl containing compounds using chemical shifts and spin coupling constant values
| Project/Area Number |
20580118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KOSHINO Hiroyuki The Institute of Physical and Chemical Research, 物質構造解析チーム, チームヘッド (50321758)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | CAST / CNMR / 構造訂正 / フォモプシンB / 環状ケトン / テルフェニル / 立体配座 / ケトン / アルデヒド / エステル / ラクトン / スピン結合定数 / テレファンチンG / ロンギフォレン / INADEQUATE法 |
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| Research Abstract |
Usefulness of geminal spin-coupling constant values on α methylene at carbonyl groups was found and developed as a method for conformational analysis to the dihedral angle between a carbonyl oxygen and methylene protons. To determination of relative stereochemistry through the carbonyl group, comparison of 13C-NMR chemical shift values was effective. Structural revision of phomopsin B was also reported.
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Report
(4 results)
Research Products
(27 results)
