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Elucidation of the new higher functions of vitamin D receptors on bone tissues in vivo.

Research Project

Project/Area Number 20580123
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionJuntendo University

Principal Investigator

IGARASHI Mamoru  Juntendo University, 医学部, 助教 (00277815)

Co-Investigator(Kenkyū-buntansha) TAKEYAMA Kenーichi  東京大学, 分子細胞生物学研究所, 講師 (30323570)
KITAGAWA Hirochika  東京大学, 分子細胞生物学研究所, 特任講師 (20345234)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords遺伝子欠損マウス / 骨代謝 / ビタミンD / 核内受容体 / ノックアウトマウス / ノックインマウス
Research Abstract

Osteoclast-specific vitamin D receptor (VDR) gene deficient (VDRΔOc/ΔOc) mice were created and analyzed. As a result, the body length and the body weight of VDRΔOc/ΔOc mice were not recognized in comparison with the wild type mice. However, after the anagen, later, the bone mass, the bone mineral densityand the trabecular bone were increased, and the osteoclast cell number were decreased in the fumer. It was revealed that VDR in the osteoclast contributed to osteoclast differentiation.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (12 results)

All 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (6 results)

  • [Journal Article] Coactivation of estrogen receptor b by gonadotropin-induced cofactor GOIT-4.2009

    • Author(s)
      Kouzu-Fujita M., Mezaki Y., Sawatsubashi S., Matsumoto T., Yamaoka I., Yano T., Taketani Y., Kitagawa H., Kato S.
    • Journal Title

      Mol.Cell.Biol. 29

      Pages: 83-92

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coactivation of estrogen receptor β by gonadotropin-induced cofactor GIOT-4.2009

    • Author(s)
      Kouzu-Fujita M
    • Journal Title

      Mol. Cell. Biol. 29

      Pages: 83-92

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli.2008

    • Author(s)
      Kouzmenko A.P., Takeyama K., Kawasaki Y., Akiyama T., Kato, S.
    • Journal Title

      Oncogene 27

      Pages: 4888-4899

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transrepressive function of TLX requires the histone demethylase LSD1.2008

    • Author(s)
      Yokoyama A., Takezawa S., Schule R., Kitagawa H., Kato S.
    • Journal Title

      Mol.Cell.Biol. 28

      Pages: 3995-4003

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transrepressive function of TLX requires the histone Demethylase LSD1.2008

    • Author(s)
      Yokoyama A
    • Journal Title

      Mol. Cell. Biol. 28

      Pages: 3995-4003

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli.2008

    • Author(s)
      Kouzmenko AP
    • Journal Title

      Oncogene 27

      Pages: 4888-4899

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新規クロマチン構造調節因子BAHD1を介した転写抑制機構の解明2008

    • Author(s)
      伊藤沙耶, 他13名
    • Organizer
      第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド兵庫県神戸市
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] オーフアン核内受容体TLXの転写抑制を介した神経幹細胞未分化維持機構の解明2008

    • Author(s)
      横山敦, 他3名
    • Organizer
      第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド兵庫県神戸市
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] ビタミンKはMsx2遺伝子の発現を調節することにより骨芽細胞分化を促進する2008

    • Author(s)
      五十嵐庸, 他5名
    • Organizer
      第62回日本栄養・食糧学会
    • Place of Presentation
      女子栄養大学埼玉県坂戸市
    • Year and Date
      2008-05-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] オーファン核内受容体TLXの転写制御を介した神経幹細胞未分化維持機構の解明2008

    • Author(s)
      横山敦、竹澤慎一郎、北川浩史、加藤茂明
    • Organizer
      第31回日本分子生物学会、第81回日本生化学会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規クロマチン構造調節因子BARD1を介した転写抑制機構の解明2008

    • Author(s)
      2伊藤紗弥、沢津橋俊、鈴木絵里子、趙越、山形薫、田辺真彦、木村周平、上田崇、藤山沙理、村田拓哉、松川紘之、林珍仙、武山健一、加藤茂明
    • Organizer
      第31回日本分子生物学会、第81回日本生化学会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] ビタミンKはMsx2遺伝子の発現を調節することにより骨芽細胞分化を促進する2008

    • Author(s)
      五十嵐庸、過足芳子、三原正朋、高田伊知郎、北川浩史、加藤茂明
    • Organizer
      第62回日本栄養・食糧学会
    • Place of Presentation
      坂戸
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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