| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Osteoclast-specific vitamin D receptor (VDR) gene deficient (VDRΔOc/ΔOc) mice were created and analyzed. As a result, the body length and the body weight of VDRΔOc/ΔOc mice were not recognized in comparison with the wild type mice. However, after the anagen, later, the bone mass, the bone mineral densityand the trabecular bone were increased, and the osteoclast cell number were decreased in the fumer. It was revealed that VDR in the osteoclast contributed to osteoclast differentiation.
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