Elucidation of the new higher functions of vitamin D receptors on bone tissues in vivo.
| Project/Area Number |
20580123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Juntendo University |
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Principal Investigator |
IGARASHI Mamoru Juntendo University, 医学部, 助教 (00277815)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEYAMA Kenーichi 東京大学, 分子細胞生物学研究所, 講師 (30323570)
KITAGAWA Hirochika 東京大学, 分子細胞生物学研究所, 特任講師 (20345234)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 遺伝子欠損マウス / 骨代謝 / ビタミンD / 核内受容体 / ノックアウトマウス / ノックインマウス |
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| Research Abstract |
Osteoclast-specific vitamin D receptor (VDR) gene deficient (VDRΔOc/ΔOc) mice were created and analyzed. As a result, the body length and the body weight of VDRΔOc/ΔOc mice were not recognized in comparison with the wild type mice. However, after the anagen, later, the bone mass, the bone mineral densityand the trabecular bone were increased, and the osteoclast cell number were decreased in the fumer. It was revealed that VDR in the osteoclast contributed to osteoclast differentiation.
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Report
(4 results)
Research Products
(12 results)
