Molecular modeling of food-grade compounds with anti-conformational disease effects by using amyloidogenic proteins
| Project/Area Number |
20580124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Shinshu University |
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Principal Investigator |
NAKAMURA Soichiro Shinshu University, 農学部, 教授 (00105305)
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| Co-Investigator(Kenkyū-buntansha) |
TERASHIMA Shoji 東海学園大学, 人間健康学部, 教授 (40227517)
FUJII Hiroshi 信州大学, 農学部, 教授 (90165340)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アミロイド線維形成 / 天然フェノール化合物 / フェノール化合物誘導体 / 分子モデリング / リポフィル化 / グリコシル化 / アミロイド型蛋白質 / 抗アミロイド効果 / アミロイド型タンパク質 / アミロイド線維 / 酵素合成 / フェノール化合物 / L68Q型シスタチン / アミロイドβ蛋白質 / アポリポタンパク質 / 安全性 / シスタチン |
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| Research Abstract |
Anti-conformational disease effects of naturally-occurring phenolic compounds and their glycosyl and lipophilic derivatives were investigated by using amyloidogenic proteins containing cystatin C L68Q variant and A β which are responsible for hereditary cystatin C amyloid angiopathy and Alzheimer's disease, respectively. As the result, it was revealed that lyophilization was more effective than glycosylation for improving anti-amyloidgenicity of the tested phenolic compounds. These observations regarding conformation-functional relationship can be useful for novel inhibitors' design as therapeutic agents for amyloid-associated diseases.
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Report
(4 results)
Research Products
(40 results)
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[Book] Amyloidogenic proteins and peptides(Bioactive proteins and peptides as functional foods and nutraceuticals)(In : Mine, Y., Li-Chan, Y., Bo, J.(ed))2010
Author(s)
Soichiro Nakamura, Takanobu Owaki, Yuki Maeda, Shigeru Katayama, Kosuke Nakamura
Publisher
Blackwell Publishing Ltd, New York
Related Report
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[Book] Amyloidogenic proteins and peptides, In: Mine, Y., Li-Chan, Y., Bo, J. (ed) Bioactive proteins and peptides as functional foods and nutraceuticals.2010
Author(s)
Soichiro Nakamura, Takanobu Owaki, Yuki Maeda, Shigeru Katayama, Kosuke Nakamura
Publisher
Blackwell Publishing Ltd, New York
Related Report
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