| Project/Area Number |
20580126
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | Shizuoka University |
|---|
Principal Investigator |
ETOH Hideo Shizuoka University, 農学部, 教授 (10076747)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MAOKA Takashi (財)生産開発科学研究所, 主任研究員 (10157159)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | 食品化学 / カロテノイド / ペルオキシナイトライド / 抗酸化 / ニトロ化 / 酸化分解 / ペルオキシなイトライト / ペルオキシナイトライト |
|---|
| Research Abstract |
Peroxynitrite, the reaction product of superoxide and nitric oxide, is a powerful oxidant in vivo. Peroxynitrite is known to induce DNA strand scission, protein modification by nitration and hydroxylation and lipid peroxydation in LDL. The in vitro reactivity of lutein, capsanthin and fucoxanthin toward peroxynitrite was investigated, and the reaction products produced by scavenging with peroxynitrite were analyzed. Nitro-carotenoids were isolated from the reaction of these carotenoids with peroxynitrite. These carotenoids inhibited the nitoration of tyrosin by peroxynitrite.
|
