Studies on Reaction Mechanism of Carotenoids and Peroxynitrite In Vivo
Project/Area Number |
20580126
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Food science
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Research Institution | Shizuoka University |
Principal Investigator |
ETOH Hideo Shizuoka University, 農学部, 教授 (10076747)
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Co-Investigator(Kenkyū-buntansha) |
MAOKA Takashi (財)生産開発科学研究所, 主任研究員 (10157159)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Keywords | 食品化学 / カロテノイド / ペルオキシナイトライド / 抗酸化 / ニトロ化 / 酸化分解 / ペルオキシなイトライト / ペルオキシナイトライト |
Research Abstract |
Peroxynitrite, the reaction product of superoxide and nitric oxide, is a powerful oxidant in vivo. Peroxynitrite is known to induce DNA strand scission, protein modification by nitration and hydroxylation and lipid peroxydation in LDL. The in vitro reactivity of lutein, capsanthin and fucoxanthin toward peroxynitrite was investigated, and the reaction products produced by scavenging with peroxynitrite were analyzed. Nitro-carotenoids were isolated from the reaction of these carotenoids with peroxynitrite. These carotenoids inhibited the nitoration of tyrosin by peroxynitrite.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Nitrocarotenoid and oxazine- carotenoid, reaction products of carotenoids with peroxynitrite2011
Author(s)
Maoka, T., Tsuboi, M., Kulkarni, A., Terada, Y., Kato, K., Nakatsugawa, H., Mori, H., Inakuma, T, Etoh, H.
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Journal Title
Carotenoid Science Vol.15(印刷中)
Related Report
Peer Reviewed
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[Journal Article] Nitration reaction of lutein with peroxynitrite2010
Author(s)
Tsuboi, M., Etoh, H., Yomoda, Y., Kato, K., Kato, H., Kulkarni, A., Terada, Y., Maoka, T., Mori, H., Inakuma, T.
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Journal Title
Tetrahedron Lett. Vol.51
Pages: 676-678
NAID
Related Report
Peer Reviewed
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[Journal Article] Nitration reaction of lutein with peroxynitrite2010
Author(s)
Tsuboi, M., Etoh, H., Yomoda, Y., Kato, K., Kato, H., Kulkarni, A., Terada, Y., Maoka, T., Mori, H., Inakuma, T.
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Journal Title
Tetrahedron Letters 51
Pages: 676-678
NAID
Related Report
Peer Reviewed
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[Journal Article] Nitrocarotenoid and oxazinecarotenoid, reaction products of carotenoids with peroxynitrite2010
Author(s)
Maoka, T., Tsuboi, M., Kulkarni, A., Terada, Y., Kato, K., Nakatsugawa, H., Mori, H., Inakuma, T., Etoh, H.
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Journal Title
Carotenoid Science (In press)
Related Report
Peer Reviewed
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[Presentation] Reaction of 1, 2-epoxylycopene with peroxynitrite2008
Author(s)
Yomota, Y., Kulkarni, A., Maoka, T., Terada, Y., Mori, H., Inakuma, T, Etoh, H.
Organizer
The 15^<th> international symposium on Carotenoids (Invited Lecture)
Place of Presentation
沖縄
Year and Date
2008-05-30
Related Report
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[Presentation] Reaction of 1,2-epoxylycopene with peroxynitrite2008
Author(s)
Yomota, Y., Kulkarni A., Maoka T., Terada Y., Mori H., Inakuma T., Etoh H
Organizer
The15th international symposium on carotenoids, Crotenoid Science
Place of Presentation
Okinawa, Japan
Related Report
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