| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
At present, obesity is trending in many developed countries, and there is increasing evidence that obesity is associated with colorectal carcinogenesis. In the present study, I attempted to identify endogenous factors which are concomitantly regulated in the processes of obesity and colorectal cancer. Leptin was suggested to be important hormone that increased during chemical carcinogenesis in the colon. In addition, citrus nobiletin was identified to be a promising phytochemical that is capable of regulating leptin levels appropriately and preventing colon tumorigenesis in mice.
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