| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
To elucidate the molecular mechanisms of neuropathy caused by vitamin B12-deficiency in elderly people, the vitamin-deficient nematode (Caenorhabditis elegans) was prepared and used as a model animal. The vitamin B12-deficient nematode showed significant metabolic disorders of lipids and amino acids, and accumulation of oxidative stress ; such disorders result in inefficiency of neurotransmission, functional disturbance of neuron receptors, and death of neuron.
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