Molecular mechanisms of neuropathy caused by vitamin B12-deficiency in elderly people
| Project/Area Number |
20580132
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | Tottori University |
|---|
Principal Investigator |
WATANABE Fumio Tottori University, 農学部, 教授 (30210941)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 栄養生化学 / ビタミン学 / 食品学 / 栄養学 / 生理活性 / 老化 / 脳神経障害 / ビタミンB12 / 線虫 / 代謝異常 |
|---|
| Research Abstract |
To elucidate the molecular mechanisms of neuropathy caused by vitamin B12-deficiency in elderly people, the vitamin-deficient nematode (Caenorhabditis elegans) was prepared and used as a model animal. The vitamin B12-deficient nematode showed significant metabolic disorders of lipids and amino acids, and accumulation of oxidative stress ; such disorders result in inefficiency of neurotransmission, functional disturbance of neuron receptors, and death of neuron.
|
Report
(4 results)
Research Products
(19 results)
