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Elucidation of a novel anti-allergic mechanism of pulverized dietary fiber and its application

Research Project

Project/Area Number 20580134
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionHiroshima University

Principal Investigator

KAWAMOTO Seiji  Hiroshima University, 大学院・先端物質科学研究科, 准教授 (90294537)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords微粉砕食物繊維 / グルコマンナン / アトピー性皮膚炎 / 機能性食品 / アレルギー性鼻炎 / 肥満細胞 / 免疫抑制作用 / NC / Ngaマウス / 自己免疫疾患
Research Abstract

In the present study, I analyzed the mode of anti-allergic mechanism of pulverized dietary fiber, especially focused on konjac glucomannan (KGM) as a model diet. I found that dietary pulverized KGM (PKGM) had beneficial effect on the prevention of atopy-associated autoimmune response as well as on the suppression of nasal mast cell infiltration in the allergic rhinitis. I also found that PKGM supplementation induced T cell tolerance against excessive antigen-specific proliferative response. These results suggest that PKGM acts on multiple immune targets to fulfill its anti-inflammatory potency. I also determined optimal particle size of PKGM to achieve its anti-allergic effect, and generated a trial product of PKGM-supplemented food.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (18 results)

All 2011 2010 2008

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (4 results)

  • [Journal Article] Sake lees fermented with lactic acid bacteria prevents allergic rhinitis-like symptoms and IgE-mediated basophil degranulation.2011

    • Author(s)
      Kawamoto S., Kaneoke M., Ohkouchi K., Amano Y., Takaoka Y., Kume K., Aki T., Watanabe K., Kadowaki M., Hirata D., Ono K.
    • Journal Title

      Biosci. Biotechnol. Biochem. 75

      Pages: 140-144

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sake lees fermented with lactic acid bacteria prevents allergic rhinitis-like symptoms and IgE-mediated basophil degranulation.2011

    • Author(s)
      Seiji Kawamoto
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 75 Pages: 140-144

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning and immunochemical characterization of a new Japanese cedar pollen allergen homologous to plant subtilisin-like serine protease.2010

    • Author(s)
      Ibrahim A.R.N., Kawamoto S., Mizuno K., Shimada Y., Rikimaru S., Onishi N., Hashimoto K., Aki T., Hayashi T., Ono K.
    • Journal Title

      World Allergy Organization J. 3

      Pages: 262-265

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunological aspects and therapeutic significance of an auto-Ab against histone H1 in a rat model of Con A-induced hepatitis.2010

    • Author(s)
      Nakano T., Goto S., Lai C.Y., Hsu L.W., Takaoka Y., Kawamoto S., Chiang K.C., Shimada Y., Ohmori N., Goto T., Sato S., Ono K., Cheng Y.F., Chen C.L.
    • Journal Title

      Immunology 129

      Pages: 547-555

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning and immunochemical characterization of a novel major Japanese cedar pollen allergen belonging to the aspartic protease family.2010

    • Author(s)
      Ibrahim A.R.N., Kawamoto S., Aki T., Shimada Y., Rikimaru S., Onishi N., Babiker E.E., Oiso I., Hashimoto K., Hayashi T., Ono K.
    • Journal Title

      Int.Arch.Allergy Immunol. 152

      Pages: 207-218

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new lipid transfer protein homolog identified as an IgE-binding antigen from Japanese cedar pollen.2010

    • Author(s)
      Ibrahim A.R.N., Kawamoto S., Nishimura M., Pak. S., Aki T., Diaz-Perales A., Salcedo G., Asturias J.A., Hayashi T., Ono K.
    • Journal Title

      Biosci. Biotechnol. Biochem. 74

      Pages: 504-509

    • NAID

      10027552495

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning and immunochemical characterization of a new Japanese cedar pollen allergen homologous to plant subtilisin-like serine protease.2010

    • Author(s)
      Ahmed Ragaa Nour Ibrahim
    • Journal Title

      World Allergy Organization Journal

      Volume: 3 Pages: 262-265

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunological aspects and therapeutic significance of an auto-Ab against histone H1 in a rat model of Con A-induced hepatitis.2010

    • Author(s)
      Toshiaki Nakano
    • Journal Title

      Immunology

      Volume: 129 Pages: 547-555

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning and immunochemical characterization of a novel major Japanese cedar pollen allergen belonging to the aspartic protease family2010

    • Author(s)
      Ahmed Ragaa Nour Ibrahim
    • Journal Title

      International Archives of Allergy and Immunology 152

      Pages: 207-218

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new lipid transfer protein homolog identified as an IgE-binding antigen from Japanese cedar pollen2010

    • Author(s)
      Ahmed Ragaa Nour Ibrahim
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry 74

      Pages: 504-509

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of autoantibody responses in NC/Nga mice : its prevention by pulverized konjac glucomannan feeding.2008

    • Author(s)
      Onishi N., Kawamoto S., Suzuki H., Hide M., Ono K.
    • Journal Title

      Arch.Dermatol. Res. 300

      Pages: 95-99

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] アレルギーワクチンの開発に向けて2008

    • Author(s)
      河本正次、秋庸裕、小埜和久
    • Journal Title

      BIO INDUSTRY 25

      Pages: 69-77

    • Related Report
      2010 Final Research Report
  • [Journal Article] Development of autoantibody responses in NC/Nga mice : its prevention by pulverized konjac glucomannan feeding.2008

    • Author(s)
      Nobukazu Onishi
    • Journal Title

      Archives of Dermatological Research 300

      Pages: 95-99

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アレルギーワクチンの開発に向けて2008

    • Author(s)
      河本 正次
    • Journal Title

      BIO INDUSTRY 25

      Pages: 69-77

    • Related Report
      2008 Annual Research Report
  • [Presentation] Recombinant allergens for immunotherapy.2010

    • Author(s)
      Kawamoto S., Aki T., Ono K.
    • Organizer
      BIT's 1st Annual World Congress of Immunodiseases and Therapy (invited lecture)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-05-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Recombinant allergens for immunotherapy2010

    • Author(s)
      Seiji Kawamoto
    • Organizer
      BIT's 1st Annual World Congress of Immunodiseases and Therapy
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-05-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Recombinant allergens for future component-resolved molecular diagnosis and tailor-made immunotherapy.2008

    • Author(s)
      Kawamoto S., Aki T., Ono K.
    • Organizer
      BIT's 1st Annual World Congress of Vaccine 2008 (invited lecture)
    • Place of Presentation
      Foshan, Guandong, China
    • Year and Date
      2008-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Recombinant allergens for future component-resolved molecular diagnosis and tailor-made immunotherapy. (invited)2008

    • Author(s)
      Seiji Kawamoto
    • Organizer
      BIT'S 1st Annual World Congress of Vaccine 2008
    • Place of Presentation
      Foshan, Guandong, China
    • Year and Date
      2008-12-04
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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