Studies on functional foods for anti-metabolic syndrome based on regulation of adipocytes' functions
| Project/Area Number |
20580136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyushu University |
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Principal Investigator |
TERUYA Kiichiro Kyushu University, 大学院・農学研究院, 助教 (10273971)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | メタボリックシンドローム / 機能性食品 / 細胞・組織 / シグナル伝達 / 発現制御 |
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| Research Abstract |
In vitro evaluation systems for anti-metabolic syndrome using adipocytes and myotubes were established. Anti-metabolic syndrome effects were investigated from candidates of functional food components by using the in vitro evaluation systems. The effectiveness of fermented milk, Kefir was revealed. (1) suppression of adipogenesis via down-regulations of transcription factors C/EBPα,β,δ and PPARγ expressions. (2) Enhancement of fatty acid beta oxidation in myotubes by activation of AMP-activated protein kinase. (3) Up-regulation of adiponectin expression and down-regulation of TNF-α expression in differentiated adipocytes.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] Suppressiveeffects of electrolyzed reduced water onalloxan-induced apoptosis and type 1 diabetes mellitus.2011
Author(s)
Y.Li, T.Hamasaki, N.Nakamichi, T.Kashiwagi, T.Komatsu, J.Ye, K.Teruya, M.Abe, H.Yan, T.Kinjo, S.Kabayama, M.Kawamura, S.Shirahata.
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Journal Title
Cytotechnology 63(2)
Pages: 119-131
Related Report
Peer Reviewed
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