| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
In vitro evaluation systems for anti-metabolic syndrome using adipocytes and myotubes were established. Anti-metabolic syndrome effects were investigated from candidates of functional food components by using the in vitro evaluation systems. The effectiveness of fermented milk, Kefir was revealed. (1) suppression of adipogenesis via down-regulations of transcription factors C/EBPα,β,δ and PPARγ expressions. (2) Enhancement of fatty acid beta oxidation in myotubes by activation of AMP-activated protein kinase. (3) Up-regulation of adiponectin expression and down-regulation of TNF-α expression in differentiated adipocytes.
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