NADPH oxidase targeted metabolic syndrome prevention
| Project/Area Number |
20580137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASAKI Masao 宮崎大学, 農学部, 准教授 (80381060)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | NADPHオキシダーゼ / メタボリックシンドローム / インテグリンβ1 / がん / 活性酸素 / インテグリン / 糖尿病 / 動脈硬化 / NADPH oxidase / metabolic syndrome / 高血圧 |
|---|
| Research Abstract |
Recent studies have shown that reactive oxygen species generated by NADPH oxidase are causative agents of metabolic syndrome. In order to elucidate the effects of NADPH oxidase inhibitors and antioxidants on metabolic syndrome prevention, the effects of NADPH oxidase inhibitors and an antioxidant on the expression level of integrin. 1, a metabolic syndrome related protein, was investigated. Both NADPH oxidase inhibitors and an antioxidant decreased the expression level of integrin. 1, suggesting that NADPH oxidase inhibitors and antioxidants are promising candidates for metabolic syndrome prevention.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Effect of Highly Lipolyzed Goat Cheese on HL-60 Human Leukemia Cells : Antiproliferative Activity and Induction of Apoptotic DNA Damage
Author(s)
Yasuda, S., Kuwata, H., Kawamoto, K., Shirakawa, J., Atobe, S., Hoshi, Y., Yamasaki, M., Nishiyama, K
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Peer Reviewed
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[Presentation] リポ酸とジヒドロリポ酸の細胞死誘導機構2008
Author(s)
川邉暁子, 西本健太朗, 山崎正夫, 岡本威明, 須田泰司, 上平賢三, 榊原陽一, 水光正仁, 西山和夫
Organizer
成20年度日本栄養・食糧学会九州・沖縄支部大会
Place of Presentation
別府市
Year and Date
2008-11-02
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[Presentation] C型肝炎治療薬インターフェロン・リバビリンの併用効果に関するPI3K/mTOR経路の係わり2008
Author(s)
江藤望, 沖真由子, 内田飛香, 榊原陽一, 江頭健太, 永浜清子, 岩田喬子, Madhyastha Harish Kumar, 山崎正夫, 西山和夫, 水光正仁
Organizer
日本生化学会九州支部例会
Place of Presentation
福岡市
Year and Date
2008-05-17
Related Report
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