| Project/Area Number |
20580140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
INUI Hiroshi Osaka Prefecture University, 生命環境科学研究科, 教授 (20193568)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ラカンカ / モグロシド / 抗糖尿病作用 / 動脈硬化予防作用 / インスリン膵臓β細胞 / 抗酸化作用 / 体内動態 / 非糖質系甘味料 / 動脈硬化症予防 / 消化・吸収 / アグリコン / インスリン / 膵臓β細胞 / 糖尿病 / 動脈硬化症 |
|---|
| Research Abstract |
Siraitia grosvenori, a traditional Chinese fruit used for a folk medicine, contains mogroside V, one of triterpene glycosides, and has been commercially available as a low-calorie sweetener for over-weight people and diabetic patients. In this study, the anti-diabetic effect of this fruit was examined, and it was found that mogrol, which is the aglycon of mogroside V, stimulated insulin secretion from pancreatic β-cells in vitro. From the aspect of anti-arteriosclerosis effect, it was elucidated that the extract of this fruit prevented oxidative stress induced by cholesterol loading in rats. In addition, the digestion, absorption, and disposition of mogroside V and its aglycon were also examined.
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