| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
The level of near to 20mM ascorbic acid (Asc) in the adrenal gland is the highest in a body. The purpose of this study was to investigate the possible participation of Asc in the zone-specific steroidogenesis. By employing rat mutants unable to synthesize Asc, Asc was shown to be a reducing factor supporting the classical reducing system specifically in aldosterone synthesis in the zona glomerulosa (zG). One of the components in the regeneration system of Asc, OMb, was abundant in zG, which seems to support above results.
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