| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We analyzed the mechanism of the inhibitory effect of lenthionine, cyclic sulfuric flavor component in shiitake, against platelet aggregation. In addition, we attempted to reduce its odor and enhance its solubility in water by the inclusion of lenthionine in α-cyclodextrin. Lenthionine suppressed phospholylation of talin, morphological change in platelets, and activation of integrin αIIbβ3. Inclusion of lenthionine by α-cyclodextrin reduced its characteristic odor and enhanced its solubility in water. Lenthionine included in α-cyclodextrin inhibited platelet aggregation ex vivo.
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