Development of neurological disease remedy using mushroom (Psilocybe argentipes)

• Project/Area Number: 20580180
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Wood science
• Research Institution: Takasaki University of Health and Welfare
• Principal Investigator: EGUCHI Fumio Takasaki University of Health and Welfare, 健康福祉学部, 教授 (60337467)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: きのこ / シロシビン / シロシン / ヒカゲシビレタケ / マジック・マッシュルーム / 抗うつ薬 / 担子菌類 / 神経系疾患 / 担子菌 / 中枢神経 / 催幻覚性 / 脅迫神経症 / 神経疾患

Research Abstract

I clarified the physiology characteristic about the mycelium of the Psilocybe argentipes. Psilocybe argentipes as the therapeutic drug of the obsessive-compulsive disorder is possible. One of the mechanism was action to the monoamine in the brain. This study was a result to help treatment of the obsessive-compulsive disorder.

Research Products

• [Journal Article] Consideration of Mushroom Functionality (2011)
  • Author(s): Fumio EGUCHI, Noriko MIYAZAWA, Takahide MATSUDA
  • Journal Title: Mushroom Science and Biotechnology 19(1) Pages: 29-31
  • NAID: 110008661468
  • Peer Reviewed
• [Journal Article] 消費者のきのこに対する意識調査と新規利用法の開発 (2011)
  • Author(s): 関根加奈子、鷲見亮、森伸夫、吉本博明、江口文陽
  • Journal Title: 家政学会誌 62(1) Pages: 3-11
  • NAID: 130004510517
  • Peer Reviewed
• [Journal Article] 消費者のきのこに対する意識調査と新規利用法の開発 (2011)
  • Author(s): 関根加奈子、鷲見亮、森伸夫、吉本博明、江口文陽
  • Journal Title: 家政学会誌 Volume: 62 Pages: 3-11
  • NAID: 130004510517
  • Peer Reviewed
• [Journal Article] 健康増進を考慮したきのこの活用法 (2010)
  • Author(s): 柿沼亜希子、江口文陽
  • Journal Title: 日本家政学会誌 61巻 Pages: 45-46
  • NAID: 130004510456
• [Journal Article] 健康増進を考慮したきのこの活用法 (2010)
  • Author(s): 柿沼亜希子、江口文陽
  • Journal Title: 家政学会誌 Volume: 61 Pages: 45-46
  • NAID: 130004510456
  • Peer Reviewed
• [Journal Article] Coprinus comatus, a newly domesticated wild nutriceutical mushroom in the Philippines : Reyes (2009)
  • Author(s): R.G.Lopez, L.L.M.A.Kumakura, K.Kalaw, S.P.Kikukawa T., Eguchi F.
  • Journal Title: An International Journal of Agricultural Technology 5(2) Pages: 299-316
  • Peer Reviewed
• [Journal Article] Status and Prospects of Medicinal Mushroom Cultivation in Central Luzon Region of the Philippines (2009)
  • Author(s): Renato G. Reyes, Sofronio P. Kalaw, Arce D. Bellere, Hiroaki Yoshimoto, Tadahiro Kikukawa, Miyato Higaki, Fumio Eguchi
  • Journal Title: Mushroom Science and Biotechnology 17(2) Pages: 87-89
  • NAID: 110007811860
• [Journal Article] Effects of Psilocybe argentipes on marble-burying behavior in mice (2009)
  • Author(s): Yoshihiro Matsushima, Osamu Shirota, Ruri Kikura-Hanajiri, Yukihiro Goda, Fumio Eguchi
  • Journal Title: Bioscience, Biotechnology, and Biochemistry 73(8) Pages: 1866-1868
  • NAID: 10027544914
  • Peer Reviewed
• [Journal Article] Mycelial Growth Requirements of Psilocybeargentipes (2009)
  • Author(s): Yoshihiro Matsushima, Makoto Tanaka, Fumio Eguchi
  • Journal Title: Pharmacometrics 75(5/6) Pages: 97-103
  • Peer Reviewed
• [Journal Article] Historical overview of psychoactive mushrooms (2009)
  • Author(s): Yoshihiro Matsushima, Fumio Eguchi, Tadahiro Kikukawa, Takahide Matsuda
  • Journal Title: Inflammation and Regeneration 29(1) Pages: 38-47
  • NAID: 10024797083
  • Peer Reviewed
• [Journal Article] Effects of Psilocybe argentipes on marble-burying behavior in mice (2009)
  • Author(s): Y.Matsushima, O.Shirota, R.Kikura-, Y.Goda, F.Eguchi
  • Journal Title: Biotechnology, and Biochemistry 73 Pages: 1866-1868
  • NAID: 10027544914
  • Peer Reviewed
• [Journal Article] Mycelial Growth Requirements of Psilocybe argentipes : Yoshihiro (2009)
  • Author(s): Matsushima, Makoto Tanaka, Fumio Eguchi
  • Journal Title: Pharmacometrics 75 Pages: 97-103
  • Peer Reviewed
• [Journal Article] Historical overview of psychoactive mushrooms (2009)
  • Author(s): Yoshihiro Matsushima, Fumio Eguchi, 他
  • Journal Title: Inflammation and Regeneration 29 Pages: 47-58
  • NAID: 10024797083
  • Peer Reviewed
• [Presentation] 中枢神経に作用するきのこ最前線…スギヒラタケからヒカゲシビレタケまで… (2011)
  • Author(s): 江口文陽
  • Organizer: 日本きのこ学会第13回ワークショップ
  • Place of Presentation: 岐阜
• [Presentation] スギヒラタケ熱水抽出物中に含まれる健康危害物質の生体への影響 (2010)
  • Author(s): 松島良紘、吉本博明、江口文陽
  • Organizer: 第14回日本きのこ学会
  • Place of Presentation: 東京大学
  • Year and Date: 2010-09-17
• [Presentation] ヒカゲシビレタケの菌株保存法の検討 (2010)
  • Author(s): 松島良紘、吉本博明、江口文陽
  • Organizer: 第14回日本きのこ学会
  • Place of Presentation: 東京
• [Presentation] スギヒラタケ熱水抽出物中に含まれる健康危害物質の生体への影響 (2010)
  • Author(s): 江口文陽、松島良紘、吉本博明
  • Organizer: 第60回日本木材学会大会
  • Place of Presentation: 宮崎
• [Presentation] ヒカゲシビレタケがマウスの玉覆い隠し行動へ与える影響 (2009)
  • Author(s): 松島良絋, 江口文陽
  • Organizer: 日本きのこ学会第13回大会
  • Place of Presentation: 武庫川女子大学(神戸)
  • Year and Date: 2009-09-10
• [Presentation] ヒカゲシビレタケ有用産生物質の安定性を考慮した菌株保存方法の確立 (2009)
  • Author(s): 松島良紘, 江口文陽
  • Organizer: 日本木材学会第58回大会
  • Place of Presentation: 松本
  • Year and Date: 2009-03-16
• [Presentation] ヒカゲシビレタケの行動薬理学的試験 (2009)
  • Author(s): 松島良紘、江口文陽
  • Organizer: 第11回応用薬理シンポジウム
  • Place of Presentation: 静岡
• [Presentation] ヒカゲシビレタケのプロトプラスト再生株のシロシン・シロシビンの産生能の解析 (2009)
  • Author(s): 田中芳枝、松島良紘、江口文陽
  • Organizer: 第13回日本きのこ学会
  • Place of Presentation: 兵庫
• [Presentation] ヒカゲシビレタケがマウスの玉覆い隠し行動へ与える影響-脳内受容体亢進作用の働き- (2009)
  • Author(s): 松島良紘、江口文陽
  • Organizer: 第13回日本きのこ学会
  • Place of Presentation: 兵庫
• [Remarks] ホームページ等
  • URL: http://www.takasaki-u.ac.jp/dept/eiyo/teacher/details.php?C=1042
• [Remarks]
  • URL: http://egclab.blog10.fc2.com/