Structure and function of lipolysis-promoting substance from scallop shell

• Project/Area Number: 20580218
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Fisheries chemistry
• Research Institution: Muroran Institute of Technology
• Principal Investigator: HASEGAWA Yasushi Muroran Institute of Technology, 大学院・工学研究科, 教授 (80261387)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: ホタテガイ貝殻 / 有効利用 / 水産系廃棄物 / 健康食品 / 脂肪分解 / 生理活性物質

Research Abstract

We found that feeding rats the organic components from scallop shell causes the reduction of the weight of adipose tissues and the reduction in serum cholesterol concentration. We found that the scallop shell extract inhibited adipogenesis through the suppression of preadipocyte proliferation and the suppression of the expression of PPARγ.

Research Products

• [Journal Article] Organic components from scallop shell increase expression of keratinocyte growth factor in human skin fibroblast (2011)
  • Author(s): Akane Torita, Akimi Miyamoto, Kohsuke Ishiguro, Sachie Yamamoto, Yasushi Hasegawa
  • Journal Title: Fisheries Science 77 Pages: 263-269
  • NAID: 10027958554
  • Peer Reviewed
• [Journal Article] Organic components from scallop shell increase expression of keratinocyte growth factor in human skin fibroblast (2011)
  • Author(s): Akane Torita, Akimi Miyamoto, Kohsuke Ishiguro, Sachie Yamamoto, Yasushi Hasegawa
  • Journal Title: Fisheries Science Volume: 77 Pages: 263-269
  • NAID: 10027958554
  • Peer Reviewed
• [Journal Article] Cloning of a cDNA encoding the tail region of nonmuscle myosin II from the mantle tissue of scallop Patinopecten yessoensis (2008)
  • Author(s): Yasushi Hasegawa, Hiroko Ikeda
  • Journal Title: Fisheries Science 74 Pages: 1201-1203
  • NAID: 10021873667
  • Peer Reviewed
• [Journal Article] Organic components from scallop shell increase mRNA expressions of uncoupling protein-1 (UCP-1) in differentiated C3H10T1/2 adipocyte cells (2008)
  • Author(s): Kanae Kobayashi, Yun Chun Liu, Yasushi Hasegawa
  • Journal Title: Fisheries Science Pages: 944-946
  • Peer Reviewed
• [Journal Article] Cloning of a cDNA encoding the tail region of nonmuscle myosin II from the mantle tissue of scallop Patinopecten yessoensis (2008)
  • Author(s): Yasushi Hasegawa and Hiroko Ikeda
  • Journal Title: Fisheries Science 74 Pages: 1201-1203
  • NAID: 10021873667
  • Peer Reviewed
• [Journal Article] Organic components from scallop shell increase mRNA expressions of uncoupling protein-1 (UCP-1) in differentiated C3H10T1/2 adinocyte cells (2008)
  • Author(s): Kanae Kobayashi, Yun Chun Liu and Yasushi Hasegawa
  • Journal Title: Fisheries Science 74 Pages: 944-946
• [Presentation] Effective utilization of fishery waste materials produced from Hokkaido (2011)
  • Author(s): Torita, K. Hara, C. Okawa, Yasushi Hasegawa
  • Organizer: Joint Seminar on Environmental Science and Disaster Mitigation Research 2011
  • Place of Presentation: Muroran
  • Year and Date: 2011-03-09
• [Presentation] Identification of human skin fibroblast cell growth factor rom the scallop shells (2011)
  • Author(s): T.Hori, A.Torita, Y.Hasegawa
  • Organizer: Joint Seminar on Environmental Science and Disaster Mitigation Research 2011
  • Place of Presentation: Muroran
  • Year and Date: 2011-03-09
• [Presentation] Effective utilization of fishery waste materials produced from Hokkaido (2011)
  • Author(s): A.Torita, K.Hara, C.Okawa, Y.Hasegawa
  • Organizer: Joint Seminar of Environmental Science And Disaster Mitigation Research2011
  • Place of Presentation: 室蘭工大
  • Year and Date: 2011-03-09
• [Presentation] Identification of human skin fibroblast cell growth factor rom the scallop shells (2011)
  • Author(s): T.Hori, A.Torita, Y.Hasegawa
  • Organizer: Joint Seminar of Environmental Science And Disaster Mitigation Research2011
  • Place of Presentation: 室蘭工大
  • Year and Date: 2011-03-09
• [Presentation] ホタテガイ貝殻抽出液中に含まれる90kDaタンパク質の精製とその構造・機能日本水産学会 (2010)
  • Author(s): 小野裕基、高橋浩司、三津橋拓也、堀智彦、長谷川靖
  • Organizer: 北海道支部会
  • Place of Presentation: 室蘭
  • Year and Date: 2010-12-11
• [Presentation] 貝殻を有効利用する新技術について(招待講演) (2010)
  • Author(s): 長谷川靖
  • Organizer: 日本水産学会 北海道支部会
  • Place of Presentation: 室蘭
  • Year and Date: 2010-12-11
• [Presentation] ホタテガイ貝殻抽出液中に含まれる90kDaタ・ンパク質の精製とその構造・機能 (2010)
  • Author(s): 小野裕基、高橋浩司、三津橋拓也、堀智彦、長谷川靖
  • Organizer: 日本水産学会北海道支部会
  • Place of Presentation: 室蘭文化センター
  • Year and Date: 2010-12-11
• [Presentation] 貝殻を有効利用する新技術について (2010)
  • Author(s): 長谷川靖
  • Organizer: 日本水産学会北海道支部会
  • Place of Presentation: 室蘭文化センター 招待講演
  • Year and Date: 2010-12-11
• [Presentation] ホタテガイ貝殻ちょうつがいに含まれる成分の同定 (2010)
  • Author(s): 李麗華、長谷川靖
  • Organizer: 日本水産学会
  • Place of Presentation: 京都大学
  • Year and Date: 2010-09-23
• [Presentation] ホタテガイ貝殻抽出液に見出したプロテアーゼ活性 (2010)
  • Author(s): 福田学、長谷川靖
  • Organizer: 日本水産学会
  • Place of Presentation: 京都大学
  • Year and Date: 2010-09-23
• [Presentation] Isolation and identification of human skin fibroblast cells growth factor from scallop shells (2010)
  • Author(s): Akane torita, Naomi Yosetani, Yasushi Hasegawa
  • Organizer: Joint Seminar on Environmental Science and Disaster Mitigation Research 2010
  • Place of Presentation: Muroran
• [Presentation] Isolation and identification of human skin fibroblast cells growth factor from scallop shells. (2010)
  • Author(s): Akane torita, Naomi Yosetani, Yasushi Hasegawa
  • Organizer: Joint Seminar on Environmental Science and Disaster Mitigation Research 2010
  • Place of Presentation: Muroran Japan
• [Presentation] ホタテガイ貝殻に含まれる皮膚真皮線維芽細胞増殖因子の単離・精製 (2009)
  • Author(s): 部田茜、寄谷直美、長谷川靖
  • Organizer: マリンバイオテクノロジー学会
  • Place of Presentation: 東京
• [Presentation] Isolation and identification of human skin fibroblast cells growth factor from organic components in the scallop shells (2009)
  • Author(s): Akane torita, Naomi Yosetani, Yasushi Hasegawa
  • Organizer: International Seminar on Resources, New Energy, Environment and Disaster Mitigation
  • Place of Presentation: Kanan, China
• [Presentation] ホタテガイ貝殻に含まれる皮膚真皮線維芽細胞増殖因子の単離・精製 (2009)
  • Author(s): 部田茜, 寄谷直美, 長谷川靖
  • Organizer: マリンバイオテクノロジー学会
  • Place of Presentation: 早稲田大学
• [Presentation] ホタテガイ貝殻に含まれる皮膚真皮線維芽細胞増殖因子の単離 (2008)
  • Author(s): 部田茜、寄谷直美、長谷川靖
  • Organizer: マリンバイオテクノロジー学会
  • Place of Presentation: 京都
• [Presentation] Reducing effect of feeding powdered scallop shell on the body fat mass of rats (2008)
  • Author(s): Akane Torita, Yun Chun Liu, Yasushi Hasegawa
  • Organizer: World Fisheries Congress 2009
  • Place of Presentation: Yokohama
• [Presentation] ホタテガイ貝殻に含まれる皮膚真皮線維芽細胞増殖因子の単離 (2008)
  • Author(s): 部田茜、寄谷直美、長谷川靖
  • Organizer: マリンバイオテクノロジー学会
  • Place of Presentation: 京都大学
• [Presentation] educing effect of feeding powdered scallop shell on the body fat mass of rats (2008)
  • Author(s): Akane torita, Yun Chun Liu, Yasushi Hasegawa
  • Organizer: World Fisheries Congress 2009
  • Place of Presentation: 横浜